Asgarshirazi Masoumeh, Farokhzadeh-Soltani Monir, Keihanidost Zarrintaj, Shariat Mamak
Pediatrics Department, Tehran University of Medical Sciences, Tehran, Iran.
Maternal, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2017 Dec;11(4):197-201.
This cross sectional study aims to survey developing feeding disorders and nutritional deficiencies disorders in children with neurodevelopmental disorders such as cerebral palsy. A total of 50 children (28 boys and 22 girls) with cerebral palsy and symptoms suggesting gastrointestinal problems such as choking, recurrent pneumonia and poor weight gain, who referred to the Pediatric department of Vali-asr Hospital, Imam Khomeini hospital complex between 1 October 2012 and 30 October 2013, were checked. Motor function classification system was used to classify patient's functional gross motor severity. All patients were examined and underwent deglutition videofluroscopy (modified barium swallow) and upper GI endoscopy with esophageal biopsies. Outcome of this study was the prevalence of oropharyngeal incoordination and GERD. Its relationship with some variables like motor and cognitive developmental delay were analyzed and p value < 0.05 was considered significant. Medical therapy and/or oral physiotherapy and nutritional rehabilitation were started. They were examined after 6 months of treatment. Decrease in choking and episodes of respiratory infections that needed hospitalization and weight gain after 6 months treatment were considered as secondary outcomes (response to treatment). Prevalence of GERD was 66% and oropharyngeal dysphagia was estimated 82%. According to results of video-fluroscopy and endoscopic biopsies, 52% of patients were affected by both GERD and oropharyngeal dysfunction. The gross motor function disability was the only variable that significantly related to the prevalence of feeding disorders (p = 0.015). Despite nutritional rehabilitation only 46% of children have weight gain. Feeding disorders such as GERD and oropharyngeal dysfunction are more prevalent in children with cerebral palsy especially in children with severe gross motor disabilities. Since, clinical manifestations of these disorders can be similar accurate diagnostic methods should be selected for all children with cerebral palsy and gastrointestinal symptoms. Treatment should start early to reduce the complications and improve outcomes.
这项横断面研究旨在调查患有神经发育障碍(如脑瘫)的儿童中正在发展的喂养障碍和营养缺乏症。共有50名患有脑瘫且有诸如呛噎、反复肺炎和体重增加不佳等提示胃肠道问题症状的儿童(28名男孩和22名女孩),他们于2012年10月1日至2013年10月30日期间被转诊至伊玛目霍梅尼医院综合大楼瓦利阿斯尔医院儿科接受检查。使用运动功能分类系统对患者的功能性总体运动严重程度进行分类。所有患者均接受检查,并进行吞咽电视荧光透视检查(改良钡餐吞咽)和上消化道内镜检查及食管活检。本研究的结果是口咽不协调和胃食管反流病(GERD)的患病率。分析了其与运动和认知发育迟缓等一些变量的关系,p值<0.05被认为具有显著性。开始进行药物治疗和/或口腔物理治疗以及营养康复。在治疗6个月后对他们进行检查。呛噎减少、需要住院治疗的呼吸道感染发作次数减少以及治疗6个月后体重增加被视为次要结果(对治疗的反应)。GERD的患病率为66%,口咽吞咽困难估计为82%。根据电视荧光透视检查和内镜活检结果,52%的患者同时患有GERD和口咽功能障碍。总体运动功能残疾是与喂养障碍患病率显著相关的唯一变量(p = 0.015)。尽管进行了营养康复,但只有46%的儿童体重增加。GERD和口咽功能障碍等喂养障碍在脑瘫儿童中更为普遍,尤其是在具有严重总体运动残疾的儿童中。由于这些疾病的临床表现可能相似,因此应为所有患有脑瘫和胃肠道症状的儿童选择准确的诊断方法。应尽早开始治疗以减少并发症并改善结果。