14903Charité-Universitätsmedizin Berlin, Berlin, Germany.
522475Berlin Institute of Health, Berlin, Germany.
J Child Neurol. 2022 Feb;37(2):112-118. doi: 10.1177/08830738211059686. Epub 2021 Dec 13.
Cerebral palsy is the most common motor disability in childhood. Still, the precise definition in terms of causes and timing of the brain damage remains controversial. Several studies examine the clinical phenotype of cerebral palsy types. The aim of our study was to determine to what extent the clinical phenotype of cerebral palsy patients depends on the underlying cause. We retrospectively evaluated the clinical phenotype, abnormalities during pregnancy, and cerebral palsy cause of 384 patients, treated at Charité-Medicine University, between 2015 and 2017. The cause of cerebral palsy was identified in 79.9% of cases. Causes prior to the perinatal period were, compared to perinatal brain damage, associated significantly with different comorbidities. The term does not describe a single disease but is an umbrella term covering many different diseases. Depending on the cause, a varying clinical phenotype can be found, which offers great potential in terms of individual treatment and preventing comorbidities.
脑瘫是儿童中最常见的运动障碍。然而，关于脑损伤的原因和时间的精确定义仍存在争议。一些研究检查了脑瘫类型的临床表型。我们的研究目的是确定脑瘫患者的临床表型在多大程度上取决于潜在的病因。我们回顾性评估了 2015 年至 2017 年在 Charité-Medicine 大学接受治疗的 384 名脑瘫患者的临床表型、妊娠期间的异常情况和脑瘫病因。脑瘫的病因在 79.9%的病例中得到了确定。与围产期脑损伤相比，围产期前的病因与不同的合并症显著相关。术语 并不描述一种单一的疾病，而是一个涵盖许多不同疾病的总称。根据病因的不同，可以发现不同的临床表型，这在个体治疗和预防合并症方面具有巨大的潜力。
