Aramendía P, Eisenschlos C D, Márquez M T
Eur J Pharmacol. 1986 Nov 12;131(1):141-4. doi: 10.1016/0014-2999(86)90528-5.
Phosphodiesterase inhibition by papaverine is likely to play a minor role in the rat atrial inotropic response because non-significant changes in cyclic AMP were obtained. Isoprenaline however raised the nucleotide levels three-fold and up to seventeen-fold when papaverine was added in a similar preparation. A prominent effect of papaverine was to lengthen relaxation instead of shortening it as did isoprenaline. The results suggest different sites of action, although overlapping effects cannot be excluded.
罂粟碱对磷酸二酯酶的抑制作用在大鼠心房变力反应中可能起次要作用，因为环磷酸腺苷（cAMP）的变化不显著。然而，在类似的制剂中加入罂粟碱时，异丙肾上腺素使核苷酸水平提高了三倍，最高可达十七倍。罂粟碱的一个显著作用是延长舒张期，而异丙肾上腺素则是缩短舒张期。结果表明作用位点不同，尽管不能排除重叠效应。
