罂粟碱对豚鼠离体心房中环磷酸腺苷、钙摄取及收缩力的影响。
Effect of papaverine on cyclic AMP, calcium uptake and force of contraction in isolated guinea-pig auricles.
作者信息
Holzmann S, Meinertz T, Nawrath H, Scholz H
出版信息
Res Commun Chem Pathol Pharmacol. 1977 Mar;16(3):443-50.
The effects of papaverine on cyclic AMP (c-AMP), 45 calcium uptake and force of contraction were studied in electrically stimulated left guinea-pig auricles. Papaverine (2 x 10(-6) - 2 x 10(-5)M produced a concentration-dependent positive inotropic effect which was not affected by 10(-7) M propranolol. Papaverine (10(-5)M increased cyclic AMP; this effect developed faster than the increase in twitch tension. Papaverine (10(-5)M) enhanced 45calcium uptake. These results are taken to support the idea of a causative series of interactions between a papaverine induced increase in c-AMP, calcium uptake and force of contraction.
在电刺激的豚鼠左心房中研究了罂粟碱对环磷酸腺苷（c-AMP）、45钙摄取和收缩力的影响。罂粟碱（2×10⁻⁶ - 2×10⁻⁵M）产生浓度依赖性正性肌力作用，该作用不受10⁻⁷M普萘洛尔的影响。罂粟碱（10⁻⁵M）增加环磷酸腺苷；这种作用比收缩张力的增加发展得更快。罂粟碱（10⁻⁵M）增强45钙摄取。这些结果支持了罂粟碱诱导的环磷酸腺苷增加、钙摄取和收缩力之间存在因果相互作用系列的观点。
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