• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重症肾小管间质性肾炎：即便无肾肉芽肿也能追踪到结核病

Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma.

作者信息

Delafosse Marion, Teuma Cécile, Miailhes Patrick, Nouvier Mathilde, Rabeyrin Maud, Fouque Denis

机构信息

Department of Nephrology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Université de Lyon, Lyon, France.

Department of Infectious Diseases, Hôpital Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

出版信息

Clin Kidney J. 2018 Oct;11(5):667-669. doi: 10.1093/ckj/sfx157. Epub 2018 Jan 23.

DOI:10.1093/ckj/sfx157
PMID:30288262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6165755/
Abstract

Extra-pulmonary tuberculosis is frequently located in the kidneys and, in such cases, could be associated with a granulomatous interstitial nephritis. Granulomas are not always detected, especially in human immunodeficiency virus (HIV)-positive patients. We report here a case of tubulointerstitial nephritis without granulomas in an HIV-negative patient. Since all laboratory tests failed to isolate in the kidney, a targeted biopsy guided by positron emission tomography-computed tomography was performed on a mediastinal node, revealing a positive culture. After 6 months of treatment, no recovery of the renal injury has been observed.

摘要

肺外结核常发生于肾脏，在这种情况下，可能伴有肉芽肿性间质性肾炎。肉芽肿并不总是能被检测到，尤其是在人类免疫缺陷病毒（HIV）阳性患者中。我们在此报告一例HIV阴性患者的无肉芽肿性肾小管间质性肾炎病例。由于所有实验室检查均未能在肾脏中分离出病原体，因此在正电子发射断层扫描 - 计算机断层扫描引导下对纵隔淋巴结进行了靶向活检，结果显示培养阳性。经过6个月的治疗，未观察到肾损伤的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/d78daac78520/sfx157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/ba7131296ddf/sfx157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/1cfe76c07661/sfx157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/d78daac78520/sfx157f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/ba7131296ddf/sfx157f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/1cfe76c07661/sfx157f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad0f/6165755/d78daac78520/sfx157f3.jpg

相似文献

1
Severe tubulointerstitial nephritis: tracking tuberculosis even in the absence of renal granuloma.重症肾小管间质性肾炎：即便无肾肉芽肿也能追踪到结核病
Clin Kidney J. 2018 Oct;11(5):667-669. doi: 10.1093/ckj/sfx157. Epub 2018 Jan 23.
2
Granulomatous tubulointerstitial nephritis in the renal allograft.移植肾中的肉芽肿性肾小管间质性肾炎
Am J Kidney Dis. 2000 Oct;36(4):E27. doi: 10.1053/ajkd.2000.17735.
3
A non-immunocompromised host with nontuberculous mycobacteria-associated tubulointerstitial nephritis.非免疫功能低下宿主的非结核分枝杆菌相关性 tubulointerstitial nephritis。
CEN Case Rep. 2022 Nov;11(4):442-447. doi: 10.1007/s13730-022-00690-6. Epub 2022 Mar 16.
4
[Chronic renal failure: unexpected late sequela of pulmonary tuberculosis after 30 years].[慢性肾衰竭：肺结核30年后意外出现的晚期后遗症]
Mikrobiyol Bul. 2011 Apr;45(2):366-70.
5
Presentation, diagnosis, and treatment outcome of tuberculous-mediated tubulointerstitial nephritis.结核介导的小管间质性肾炎的表现、诊断和治疗结果。
Kidney Int. 2011 Mar;79(6):671-677. doi: 10.1038/ki.2010.482. Epub 2010 Dec 15.
6
A case of acute kidney injury caused by granulomatous tubulointerstitial nephritis associated with sarcoidosis and concomitant presence of anti-glomerular basement membrane antibody.一例由结节病相关的肉芽肿性肾小管间质性肾炎及同时存在的抗肾小球基底膜抗体引起的急性肾损伤。
Sarcoidosis Vasc Diffuse Lung Dis. 2016 Jan 18;32(4):368-71.
7
Granulomatous Interstitial Nephritis - A Series of Six Cases.肉芽肿性间质性肾炎——6例病例系列
Indian J Nephrol. 2020 Jan-Feb;30(1):26-28. doi: 10.4103/ijn.IJN_364_18. Epub 2019 Dec 27.
8
Granulomatous interstitial nephritis on renal biopsy in human immunodeficiency virus positive patients: Prevalence and causes in Cape Town, South Africa.在南非开普敦，人类免疫缺陷病毒阳性患者的肾活检中出现的肉芽肿性间质性肾炎：患病率和病因。
Nephrology (Carlton). 2019 Jul;24(7):681-688. doi: 10.1111/nep.13564. Epub 2019 May 7.
9
A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis.一例由结节病相关的肉芽肿性间质性肾炎引起的急性肾损伤病例。
CEN Case Rep. 2018 May;7(1):34-38. doi: 10.1007/s13730-017-0287-9. Epub 2017 Nov 27.
10
Tubulointerstitial Nephritis and Uveitis Syndrome with non caseating granuloma in bone marrow biopsy.肾小管间质性肾炎和葡萄膜炎综合征，骨髓活检可见非干酪样肉芽肿。
Acta Med Port. 2014 Mar-Apr;27(2):268-70. doi: 10.20344/amp.3981. Epub 2014 Apr 30.

引用本文的文献

1
Sensitivity of Immunodiagnostic Tests in Localized Versus Disseminated Tuberculosis-A Systematic Review of Individual Patient Data.免疫诊断检测在局限性与播散性结核病中的敏感性——个体患者数据的系统评价
Trop Med Infect Dis. 2025 Mar 7;10(3):70. doi: 10.3390/tropicalmed10030070.
2
Serologic and urinary characteristics of laboratory-confirmed genitourinary tuberculosis at a tertiary hospital in the Philippines.菲律宾一家三级医院确诊的泌尿生殖系统结核的血清学和尿液特征。
BMC Urol. 2021 Sep 9;21(1):125. doi: 10.1186/s12894-021-00888-3.
3
[Subacute kidney injury in a 40-year-old female Northern African patient].

本文引用的文献

1
PET/CT imaging of infection.感染的正电子发射断层显像/计算机断层扫描（PET/CT）成像
Clin Transl Imaging. 2016;4:131-144. doi: 10.1007/s40336-016-0164-0. Epub 2016 Mar 7.
2
Evaluating Indeterminate Interferon-γ-Release Assay Results in Patients With Chronic Inflammatory Diseases Receiving Immunosuppressive Therapy.评估接受免疫抑制治疗的慢性炎症性疾病患者中干扰素-γ释放试验结果不确定的情况。
Arthritis Care Res (Hoboken). 2015 Aug;67(8):1063-9. doi: 10.1002/acr.22454.
3
Risk of tuberculosis in pregnancy: a national, primary care-based cohort and self-controlled case series study.
[一名40岁北非女性患者的亚急性肾损伤]
Internist (Berl). 2021 Jul;62(7):772-776. doi: 10.1007/s00108-021-00964-8. Epub 2021 Feb 22.
妊娠结核病风险：一项全国性、以初级保健为基础的队列和自身对照病例系列研究。
Am J Respir Crit Care Med. 2012 Apr 1;185(7):779-84. doi: 10.1164/rccm.201106-1083OC. Epub 2011 Dec 8.
4
Predictive factors for indeterminate result on the QuantiFERON test in an intermediate tuberculosis-burden country.在结核病负担中等的国家，QuantiFERON 检测结果不确定的预测因素。
J Infect. 2011 May;62(5):347-54. doi: 10.1016/j.jinf.2011.03.004. Epub 2011 Mar 15.
5
Tuberculosis and tubulointerstitial nephritis: an intriguing puzzle.结核病与肾小管间质性肾炎：一个有趣的难题。
Kidney Int. 2011 Mar;79(6):579-581. doi: 10.1038/ki.2010.495.
6
Presentation, diagnosis, and treatment outcome of tuberculous-mediated tubulointerstitial nephritis.结核介导的小管间质性肾炎的表现、诊断和治疗结果。
Kidney Int. 2011 Mar;79(6):671-677. doi: 10.1038/ki.2010.482. Epub 2010 Dec 15.
7
Molecular analysis of Mycobacterium isolates from extrapulmonary specimens obtained from patients in Mexico.对从墨西哥患者的肺外标本中分离出的分枝杆菌进行分子分析。
BMC Clin Pathol. 2009 Mar 9;9:1. doi: 10.1186/1472-6890-9-1.
8
Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals.接受抗逆转录病毒治疗的HIV感染者中与分枝杆菌感染相关的免疫重建疾病
Lancet Infect Dis. 2005 Jun;5(6):361-73. doi: 10.1016/S1473-3099(05)70140-7.
9
Immune complex nephritis complicating miliary tuberculosis.粟粒性肺结核并发免疫复合物性肾炎。
Br Med J (Clin Res Ed). 1983 Nov 26;287(6405):1593-4. doi: 10.1136/bmj.287.6405.1593-a.