Dahlöf C, Dahlöf P, Lundberg J M
Eur J Pharmacol. 1986 Nov 19;131(2-3):279-83. doi: 10.1016/0014-2999(86)90583-2.
Clonidine (10 micrograms X kg-1) reduced by almost 50% the increase in plasma neuropeptide (NPY)-like immunoreactivity (-LI) induced by preganglionic nerve stimulation at 8 Hz. This effect was reversed by yohimbine (1 mg X kg-1) which caused a three-fold increase of the plasma NPY-LI. Prazosin (1 mg X kg-1) had no such effect. Guanethidine (5 mg X kg-1) reduced the stimulation-evoked increase in plasma NPY-LI. It is concluded that the release of NPY-LI evoked by nerve stimulation from sympathetic nerve terminals is controlled by a presynaptic alpha 2-adrenoceptor-mediated mechanism.
可乐定（10微克/千克）使8赫兹节前神经刺激所诱导的血浆神经肽Y（NPY）样免疫反应性（-LI）增加几乎降低了50%。育亨宾（1毫克/千克）可逆转此效应，它使血浆NPY-LI增加了三倍。哌唑嗪（1毫克/千克）无此效应。胍乙啶（5毫克/千克）降低了刺激诱发的血浆NPY-LI增加。结论是，交感神经末梢神经刺激诱发的NPY-LI释放受突触前α2-肾上腺素能受体介导机制的控制。
