犬交感神经激活后血浆儿茶酚胺和神经肽Y水平的变化
Changes in plasma catecholamine and neuropeptide Y levels after sympathetic activation in dogs.
作者信息
Poncet M F, Damase-Michel C, Tavernier G, Tran M A, Berlan M, Montastruc J L, Montastruc P
机构信息
Laboratoire de Pharmacologie Médicale et Clinique, Inserm U 317, Faculté de Médecine, Toulouse, France.
出版信息
Br J Pharmacol. 1992 Jan;105(1):181-3. doi: 10.1111/j.1476-5381.1992.tb14232.x.
Abstract
- Plasma levels of noradrenaline (NA) and neuropeptide Y (NPY) were evaluated in two experimental models associated with an increase in sympathetic tone: conscious dogs which were subject to either sinoaortic denervation or acute administration of the alpha 2-adrenoceptor antagonist yohimbine. 2. Dogs that had undergone sinoaortic denervation exhibited a two fold increase in plasma NA without any change in NPY levels. 3. Yohimbine (0.05 mg kg-1 i.v. as a bolus) produced similar effects. A higher dose of yohimbine (0.5 mg kg-1 i.v.) increased both plasma NA (7 fold) and NPY (6.5 fold) levels. 4. The present results indicate that changes in plasma catecholamines and NPY are not always concomitant. They suggest that the simultaneous release of NA and NPY is only observed under in vivo conditions for a marked increase in sympathetic tone.
摘要
- 在与交感神经张力增加相关的两种实验模型中评估了去甲肾上腺素（NA）和神经肽Y（NPY）的血浆水平：清醒犬，其接受了窦主动脉去神经支配或α2 -肾上腺素能受体拮抗剂育亨宾的急性给药。2. 接受窦主动脉去神经支配的犬血浆NA增加了两倍，而NPY水平没有任何变化。3. 育亨宾（0.05 mg kg-1静脉推注）产生了类似的效果。更高剂量的育亨宾（0.5 mg kg-1静脉注射）使血浆NA（7倍）和NPY（6.5倍）水平均升高。4. 目前的结果表明，血浆儿茶酚胺和NPY的变化并不总是同时发生的。它们表明，仅在体内条件下交感神经张力显著增加时才会观察到NA和NPY的同时释放。
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本文引用的文献
1
Release of neuropeptide Y in response to splanchnic nerve stimulation in the conscious calf.清醒小牛中，内脏神经刺激后神经肽Y的释放。
J Physiol. 1984 Dec;357:401-8. doi: 10.1113/jphysiol.1984.sp015507.
2
Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor.育亨宾：一种用于研究α2-肾上腺素能受体的药理学探针。
Pharmacol Rev. 1983 Sep;35(3):143-80.
3
Co-release of neuropeptide Y and catecholamines during physical exercise in man.人体运动过程中神经肽Y与儿茶酚胺的共同释放。
Biochem Biophys Res Commun. 1985 Nov 27;133(1):30-6. doi: 10.1016/0006-291x(85)91837-6.
4
Increases in plasma neuropeptide Y concentrations during sympathetic activation in man.人体交感神经激活过程中血浆神经肽Y浓度的升高。
J Auton Nerv Syst. 1986 Oct;17(2):143-9. doi: 10.1016/0165-1838(86)90089-5.
5
Nicardipine causes sympathetic activation that does not involve baroreceptor reflex tachycardia in conscious sinoaortic-denervated dogs.尼卡地平可引起清醒的去窦主动脉神经犬的交感神经激活，但不涉及压力感受器反射性心动过速。
Eur J Pharmacol. 1987 Oct 6;142(1):145-9. doi: 10.1016/0014-2999(87)90665-0.
6
Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats.大鼠急性应激时血浆儿茶酚胺和神经肽Y的差异反应
Life Sci. 1988;42(17):1615-24. doi: 10.1016/0024-3205(88)90440-7.
7
Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines.应激诱导大鼠循环中神经肽Y的变化：与儿茶酚胺的比较。
Regul Pept. 1987 Oct;19(1-2):55-63. doi: 10.1016/0167-0115(87)90074-7.
8
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Pharmacol Toxicol. 1988;63 Suppl 1:27-31. doi: 10.1111/j.1600-0773.1988.tb02034.x.
9
Alpha 2-adrenoceptor-mediated inhibition of nerve stimulation-evoked release of neuropeptide Y (NPY)-like immunoreactivity in the pithed guinea-pig.α2肾上腺素能受体介导的对去脑豚鼠神经刺激诱发的神经肽Y（NPY）样免疫反应性释放的抑制作用。
Eur J Pharmacol. 1986 Nov 19;131(2-3):279-83. doi: 10.1016/0014-2999(86)90583-2.
10
Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport.猪脾脏在体内神经肽Y和去甲肾上腺素的共同释放：亚细胞储存、神经冲动频率和模式、反馈调节以及轴突运输再供应的重要性。
Neuroscience. 1989;28(2):475-86. doi: 10.1016/0306-4522(89)90193-0.
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