文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Poncet M F, Damase-Michel C, Tavernier G, Tran M A, Berlan M, Montastruc J L, Montastruc P

Laboratoire de Pharmacologie Médicale et Clinique, Inserm U 317, Faculté de Médecine, Toulouse, France.

Br J Pharmacol. 1992 Jan;105(1):181-3. doi: 10.1111/j.1476-5381.1992.tb14232.x.

Plasma levels of noradrenaline (NA) and neuropeptide Y (NPY) were evaluated in two experimental models associated with an increase in sympathetic tone: conscious dogs which were subject to either sinoaortic denervation or acute administration of the alpha 2-adrenoceptor antagonist yohimbine. 2. Dogs that had undergone sinoaortic denervation exhibited a two fold increase in plasma NA without any change in NPY levels. 3. Yohimbine (0.05 mg kg-1 i.v. as a bolus) produced similar effects. A higher dose of yohimbine (0.5 mg kg-1 i.v.) increased both plasma NA (7 fold) and NPY (6.5 fold) levels. 4. The present results indicate that changes in plasma catecholamines and NPY are not always concomitant. They suggest that the simultaneous release of NA and NPY is only observed under in vivo conditions for a marked increase in sympathetic tone.

在与交感神经张力增加相关的两种实验模型中评估了去甲肾上腺素（NA）和神经肽Y（NPY）的血浆水平：清醒犬，其接受了窦主动脉去神经支配或α2 -肾上腺素能受体拮抗剂育亨宾的急性给药。2. 接受窦主动脉去神经支配的犬血浆NA增加了两倍，而NPY水平没有任何变化。3. 育亨宾（0.05 mg kg-1静脉推注）产生了类似的效果。更高剂量的育亨宾（0.5 mg kg-1静脉注射）使血浆NA（7倍）和NPY（6.5倍）水平均升高。4. 目前的结果表明，血浆儿茶酚胺和NPY的变化并不总是同时发生的。它们表明，仅在体内条件下交感神经张力显著增加时才会观察到NA和NPY的同时释放。

Poncet M F, Damase-Michel C, Tavernier G, Tran M A, Berlan M, Montastruc J L, Montastruc P

Laboratoire de Pharmacologie Médicale et Clinique, Inserm U 317, Faculté de Médecine, Toulouse, France.

Br J Pharmacol. 1992 Jan;105(1):181-3. doi: 10.1111/j.1476-5381.1992.tb14232.x.

Plasma levels of noradrenaline (NA) and neuropeptide Y (NPY) were evaluated in two experimental models associated with an increase in sympathetic tone: conscious dogs which were subject to either sinoaortic denervation or acute administration of the alpha 2-adrenoceptor antagonist yohimbine. 2. Dogs that had undergone sinoaortic denervation exhibited a two fold increase in plasma NA without any change in NPY levels. 3. Yohimbine (0.05 mg kg-1 i.v. as a bolus) produced similar effects. A higher dose of yohimbine (0.5 mg kg-1 i.v.) increased both plasma NA (7 fold) and NPY (6.5 fold) levels. 4. The present results indicate that changes in plasma catecholamines and NPY are not always concomitant. They suggest that the simultaneous release of NA and NPY is only observed under in vivo conditions for a marked increase in sympathetic tone.

在与交感神经张力增加相关的两种实验模型中评估了去甲肾上腺素（NA）和神经肽Y（NPY）的血浆水平：清醒犬，其接受了窦主动脉去神经支配或α2 -肾上腺素能受体拮抗剂育亨宾的急性给药。2. 接受窦主动脉去神经支配的犬血浆NA增加了两倍，而NPY水平没有任何变化。3. 育亨宾（0.05 mg kg-1静脉推注）产生了类似的效果。更高剂量的育亨宾（0.5 mg kg-1静脉注射）使血浆NA（7倍）和NPY（6.5倍）水平均升高。4. 目前的结果表明，血浆儿茶酚胺和NPY的变化并不总是同时发生的。它们表明，仅在体内条件下交感神经张力显著增加时才会观察到NA和NPY的同时释放。