Razi Farideh, Nasli-Esfahani Ensieh, Bandarian Fatemeh
1Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, 5th floor, Diabetes Clinic, cross Heyat Ave, Shahrivar Ave., North Kargar St, Tehran, 1411715851 Iran.
2Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Diabetes Metab Disord. 2018 Mar 29;17(1):71-75. doi: 10.1007/s40200-018-0340-z. eCollection 2018 Jun.
Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Recent studies suggest that it is probable that uric acid is involved in the pathogenesis of diabetic nephropathy. This study aim was to investigate the association between serum uric acid and kidney function in Iranian patients with type 2 diabetes mellitus.
In this case-control study, a total of 201 diabetic patients with or without impaired kidney function (glomerular filtration rate/GFR < 60 and GFR ≥ 60) were selected. In both groups, serum fasting glucose (FBS), HbA1c, urea, creatinine, uric acid and lipid profile, urine albumin and GFR were measured and results were compared between the two groups. The results also categorized into three groups based on uric acid tertiles.
Serum levels of uric acid, urea and creatinine as well as urine albumin/creatinine ratio (ACR) were significantly different between the two groups. GFR, creatinine and also urea were significantly different between uric acid tertiles ( < 0.05).
Serum uric acid is associated with decreased GFR as well as albuminuria and can be used as an indicator of DN.
糖尿病肾病（DN）是终末期肾病的主要病因。近期研究表明，尿酸很可能参与了糖尿病肾病的发病机制。本研究旨在调查伊朗2型糖尿病患者血清尿酸与肾功能之间的关联。
在这项病例对照研究中，共选取了201例有或无肾功能损害（肾小球滤过率/GFR＜60和GFR≥60）的糖尿病患者。两组均测量了空腹血糖（FBS）、糖化血红蛋白（HbA1c）、尿素、肌酐、尿酸和血脂谱、尿白蛋白和GFR，并比较了两组结果。结果还根据尿酸三分位数分为三组。
两组之间血清尿酸、尿素和肌酐水平以及尿白蛋白/肌酐比值（ACR）存在显著差异。尿酸三分位数之间的GFR、肌酐以及尿素也存在显著差异（P＜0.05）。
血清尿酸与GFR降低以及蛋白尿相关，可作为糖尿病肾病的一个指标。
