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Editorial: Translational Control of APP Expression for Alzheimer Disease Therapy.

作者信息

Pankiewicz Joanna E, Sadowski Martin J

机构信息

Department of Neurology, New York University School of Medicine, New York, NY 10016.

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.

出版信息

Ann Pharmacol Pharm. 2017;2(15). Epub 2017 Aug 18.

PMID:30288489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6168206/
Abstract
摘要

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本文引用的文献

1
Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2.β-位点淀粉样前体蛋白裂解酶1和2的生理功能
Front Mol Neurosci. 2017 Apr 19;10:97. doi: 10.3389/fnmol.2017.00097. eCollection 2017.
2
2014 Alzheimer's disease facts and figures.2014 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2014 Mar;10(2):e47-92. doi: 10.1016/j.jalz.2014.02.001.
3
Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.调节淀粉样前体蛋白表达可减少小鼠模型中的β-淀粉样蛋白沉积。
Ann Neurol. 2014 May;75(5):684-99. doi: 10.1002/ana.24149. Epub 2014 Apr 28.
4
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.比较分析 APP/APLP 敲除的单基因和双基因敲除鼠发现 APP-KO 鼠的树突棘密度降低，而 APPsα 的表达可预防这一现象。
Acta Neuropathol Commun. 2014 Mar 31;2:36. doi: 10.1186/2051-5960-2-36.
5
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis.针对控制淀粉样前体蛋白翻译的阿尔茨海默病治疗药物：维持脑内铁平衡。
Biochem Pharmacol. 2014 Apr 15;88(4):486-94. doi: 10.1016/j.bcp.2014.01.032. Epub 2014 Feb 7.
6
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.两项评估 bapineuzumab 治疗轻度至中度阿尔茨海默病的 3 期临床试验。
N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839.
7
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.新型 5'非翻译区铁调节蛋白-1 依赖的淀粉样前体蛋白翻译抑制剂：唐氏综合征和阿尔茨海默病的相关影响。
PLoS One. 2013 Jul 31;8(7):e65978. doi: 10.1371/journal.pone.0065978. Print 2013.
8
Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans.Posiphen 作为一种候选药物，可降低 CSF 淀粉样前体蛋白、淀粉样-β 肽和 τ 水平：在人体中的靶标结合、耐受性和药代动力学。
J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):894-902. doi: 10.1136/jnnp-2012-302589. Epub 2012 Jul 11.
9
Physiological functions of APP family proteins.APP 家族蛋白的生理功能。
Cold Spring Harb Perspect Med. 2012 Feb;2(2):a006288. doi: 10.1101/cshperspect.a006288.
10
Functions of the APP gene family in the nervous system: insights from mouse models.APP 基因家族在神经系统中的功能：来自小鼠模型的见解。
Exp Brain Res. 2012 Apr;217(3-4):423-34. doi: 10.1007/s00221-011-2861-2. Epub 2011 Sep 20.