Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Org Biomol Chem. 2018 Dec 19;17(1):11-23. doi: 10.1039/c8ob02140f.
The present review gives an overview over non-toxic cyanation agents and cyanide sources used in the synthesis of structurally diverse products containing the nitrile function. Nucleophilic as well as electrophilic agents/systems that transfer the entire CN-group were taken in consideration. Reactions in which a preexisting carbon functionality is transformed into a nitrile function by addition of nitrogen are however not covered here.
本综述概述了在合成含有腈官能团的结构多样的产物中使用的无毒氰化试剂和氰化物源。考虑了转移整个 CN 基团的亲核试剂和亲电试剂/体系。但是,此处不包括通过加成氮将预先存在的碳官能团转化为腈官能团的反应。