Dong Li, Guo Qin, Jia Xiaoqing, Ji Qingmin, Quan Hengdao
School of Chemistry and Chemical Engineering, Beijing Institute of Technology 5 South Zhongguancun Street, Haidian District Beijing 100081 China
Quanzhou Yuji Advanced Materials Co., Ltd Quanzhou 362804 China.
RSC Adv. 2025 Aug 22;15(36):29995-30000. doi: 10.1039/d5ra03945b. eCollection 2025 Aug 18.
To replace sulfur hexafluoride (SF), a potent greenhouse gas with high global warming potential (GWP) and long lifetime, perfluoroisobutyronitrile (CFN) has emerged as the next-generation insulating gas to advance the development of the power industry, especially gas-insulated equipment. However, most reported synthesis routes for perfluoroisobutyronitrile require expensive reagents or complex procedures and harsh reaction conditions, which are impractical for scalable production and cost reduction for real applications. Herein, we report a three-step synthetic process from perfluoropropylene to perfluoroisobutyronitrile, involving addition with carbonyl fluoride, nucleophilic substitution with ammonia and dehydration. It achieved a 77% total yield of high-purity perfluoroisobutyronitrile (99.9%), which is significantly higher than that of other synthetic routes. This new synthesis process also offers compelling cost benefits and scalable production, which may promote the broader application of CFN.
六氟化硫（SF）是一种具有高全球变暖潜能值（GWP）和长寿命的强效温室气体，为了替代它，全氟异丁腈（CFN）已成为推动电力行业发展，特别是气体绝缘设备发展的下一代绝缘气体。然而，大多数报道的全氟异丁腈合成路线需要昂贵的试剂或复杂的步骤以及苛刻的反应条件，这对于规模化生产和实际应用中的成本降低而言是不切实际的。在此，我们报道了一种从全氟丙烯到全氟异丁腈的三步合成工艺，包括与氟化羰加成、与氨进行亲核取代以及脱水。该工艺实现了高纯度全氟异丁腈（99.9%）77%的总收率，这显著高于其他合成路线。这种新的合成工艺还具有引人注目的成本优势和可扩展性生产，这可能会促进CFN的更广泛应用。
