Department of Animal Biology, Faculty of Sciences, University of Málaga, Instituto Malagueño de Biomedicina (IBIMA), Campus de Teatinos s/n, 29080, Málaga, Spain.
BIONAND, Centro Andaluz de Nanomedicina y Biotecnología (Junta de Andalucía, Universidad de Málaga), Severo Ochoa n°25, 29590 Campanillas (Málaga), Spain.
Anat Rec (Hoboken). 2019 Jan;302(1):58-68. doi: 10.1002/ar.23915. Epub 2018 Oct 5.
The space between cardiac myocytes is commonly referred-to as the cardiac interstitium (CI). The CI is a unique, complex and dynamic microenvironment in which multiple cell types, extracellular matrix molecules, and instructive signals interact to crucially support heart homeostasis and promote cardiac responses to normal and pathologic stimuli. Despite the biomedical and clinical relevance of the CI, its detailed cellular structure remains to be elucidated. In this review, we will dissect the organization of the cardiac interstitium by following its changing cellular and molecular composition from embryonic developmental stages to adulthood, providing a systematic analysis of the biological components of the CI. The main goal of this review is to contribute to our understanding of the CI roles in health and disease. Anat Rec, 302:58-68, 2019. © 2018 Wiley Periodicals, Inc.
心肌细胞之间的空间通常被称为心脏间质（CI）。CI 是一个独特、复杂和动态的微环境，其中多种细胞类型、细胞外基质分子和指令性信号相互作用，对于维持心脏的内稳态和促进心脏对正常和病理刺激的反应至关重要。尽管 CI 具有重要的生物医学和临床意义，但它的详细细胞结构仍有待阐明。在这篇综述中，我们将通过从胚胎发育阶段到成年期的细胞和分子组成的变化，剖析心脏间质的组织，对 CI 的生物学成分进行系统分析。本综述的主要目的是帮助我们理解 CI 在健康和疾病中的作用。解剖学记录，302：58-68，2019。© 2018 年 Wiley Periodicals，Inc.
