Domingues Mélanie J, Cao Huimin, Heazlewood Shen Y, Cao Benjamin, Nilsson Susan K
Manufacturing, Commonwealth Scientific and Industrial Research Organization, Bag 10, Clayton South, VIC 3169, Australia.
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
J Cell Biochem. 2017 Aug;118(8):1984-1993. doi: 10.1002/jcb.25905. Epub 2017 Apr 24.
Maintenance of hematopoietic stem cells (HSC) takes place in a highly specialized microenvironment within the bone marrow. Technological improvements, especially in the field of in vivo imaging, have helped unravel the complexity of the niche microenvironment and have completely changed the classical concept from what was previously believed to be a static supportive platform, to a dynamic microenvironment tightly regulating HSC homeostasis through the complex interplay between diverse cell types, secreted factors, extracellular matrix molecules, and the expression of different transmembrane receptors. To add to the complexity, non-protein based metabolites have also been recognized as a component of the bone marrow niche. The objective of this review is to discuss the current understanding on how the different extracellular matrix components of the niche regulate HSC fate, both during embryonic development and in adulthood. Special attention will be provided to the description of non-protein metabolites, such as lipids and metal ions, which contribute to the regulation of HSC behavior. J. Cell. Biochem. 118: 1984-1993, 2017. © 2017 Wiley Periodicals, Inc.
造血干细胞（HSC）的维持发生在骨髓内一个高度特化的微环境中。技术的进步，尤其是在体内成像领域，有助于揭示生态位微环境的复杂性，并彻底改变了经典概念，即从以前认为的静态支持平台，转变为通过不同细胞类型、分泌因子、细胞外基质分子和不同跨膜受体的表达之间的复杂相互作用来严格调节HSC稳态的动态微环境。更复杂的是，非蛋白质类代谢产物也被认为是骨髓生态位的一个组成部分。本综述的目的是讨论目前对于生态位中不同细胞外基质成分如何在胚胎发育和成体阶段调节HSC命运的理解。将特别关注对非蛋白质代谢产物（如脂质和金属离子）的描述，它们有助于调节HSC的行为。《细胞生物化学杂志》118: 1984 - 1993, 2017。© 2017威利期刊公司
