石墨烯和氧化石墨烯在 SERS 传感和成像中的应用。
Graphene and Graphene Oxide Applications for SERS Sensing and Imaging.
机构信息
Chemical and Biological Research Centre, University of Warsaw, Zwirki i Wigury str. 101, Warsaw, PL-02- 089, Poland.
Faculty of Chemistry, University of Warsaw, Pasteur str. 1, Warsaw, PL-02-093, Poland.
出版信息
Curr Med Chem. 2019;26(38):6878-6895. doi: 10.2174/0929867325666181004152247.
Surface Enhanced Raman Spectroscopy (SERS) has a long history as an ultrasensitive platform for the detection of biological species from small aromatic molecules to complex biological systems as circulating tumor cells. Thanks to unique properties of graphene, the range of SERS applications has largely expanded. Graphene is efficient fluorescence quencher improving quality of Raman spectra. It contributes also to the SERS enhancement factor through the chemical mechanism. In turn, the chemical flexibility of Reduced Graphene Oxide (RGO) enables tunable adsorption of molecules or cells on SERS active surfaces. Graphene oxide composites with SERS active nanoparticles have been also applied for Raman imaging of cells. This review presents a survey of SERS assays employing graphene or RGO emphasizing the improvement of SERS enhancement brought by graphene or RGO. The structure and physical properties of graphene and RGO will be discussed too.
表面增强拉曼光谱（SERS）作为一种超灵敏的平台，已经有很长的历史，可以检测从小分子芳香族化合物到复杂生物系统（如循环肿瘤细胞）等各种生物物种。由于石墨烯的独特性质，SERS 的应用范围大大扩展。石墨烯是一种有效的荧光猝灭剂，可改善拉曼光谱的质量。它还通过化学机制贡献了 SERS 增强因子。反过来，还原氧化石墨烯（RGO）的化学灵活性使得可以在 SERS 活性表面上对分子或细胞进行可调谐吸附。具有 SERS 活性纳米粒子的氧化石墨烯复合材料也已被用于细胞的 Raman 成像。本综述介绍了采用石墨烯或 RGO 的 SERS 分析的调查，强调了石墨烯或 RGO 带来的 SERS 增强的改善。还将讨论石墨烯和 RGO 的结构和物理性质。
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