Li X, Zhang J, Wang X
School of Stomatology, Shandong University, Jinan, Shandong Province 250012, China.
Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan, Shandong Province 250012, China.
Curr Mol Med. 2018;18(4):233-240. doi: 10.2174/1566524018666181004113128.
The concept of minimodeling is defined as a kind of focal bone formation that features the absence of preceding bone absorption by osteoclasts. In the process of minimodeling, osteogenetic and osteoclastic activities are decoupled. Linear boundary between old bone and new bone can be discovered. Frost et al. presumed that minimodeling in trabeculae can continue throughout life. The concept of minimodeling is not new, however its function and nature are still imperfectly understood. Our review will focus on minimodeling-based formation in 5 aspects below: 1. compare the minimodeling with remodeling regarding 10 items; 2. describe the histological observation to characterize remodeling and minimodeling formation sites; 3. present evidence of bone anabolic agents which start bone minimodeling; 4. discuss the mechanism and target cells involved in bone minimodeling; 5. interpretate the increased osteogenic potential and trabecular connectivity with minimodeling-based formation; 6. Depict modeling patterns of the bone implant interface and peri-implant osteogenesis in osteoporosis. This review provides an in-depth knowledge regarding minimodeling comprehensively and its potential contributions in skeletal homeostasis and application prospect in improving the success rate of dental implant in osteoporosis.
微塑建的概念被定义为一种局灶性骨形成，其特征是破骨细胞不存在先前的骨吸收。在微塑建过程中，成骨和成破骨活动是解耦的。可以发现旧骨和新骨之间的线性边界。弗罗斯特等人推测，小梁中的微塑建可以持续终生。微塑建的概念并不新鲜，但其功能和本质仍未被完全理解。我们的综述将集中在以下5个方面基于微塑建的形成：1. 从10个方面比较微塑建和重塑；2. 描述组织学观察以表征重塑和微塑建的形成部位；3. 提供启动骨微塑建的骨合成剂的证据；4. 讨论骨微塑建涉及的机制和靶细胞；5. 解释基于微塑建的形成增加的成骨潜能和小梁连通性；6. 描绘骨质疏松症中骨植入物界面的建模模式和植入物周围成骨。本综述全面提供了关于微塑建的深入知识及其在骨骼稳态中的潜在贡献，以及在提高骨质疏松症患者牙种植成功率方面的应用前景。
