揭露隐藏在动物设施中的病毒。

Exposing a Virus Hiding in the Animal Facility.

机构信息

Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

出版信息

Cell. 2018 Oct 4;175(2):310-311. doi: 10.1016/j.cell.2018.09.033.

DOI:10.1016/j.cell.2018.09.033

PMID:30290137

Abstract

Roediger et al. (2018) demonstrate that a kidney disease characterized by apparently spontaneous nephropathy that had been recognized in laboratory mice for many years is caused by a newly recognized virus named the mouse kidney parvovirus (MKPV). That virus appears to be widespread in mouse colonies as it is not detected by current diagnostic tools, and its recognition presents new opportunities for understanding the pathology of tubulointerstitial fibrosis.

摘要

罗德里格等人（2018 年）证明，一种多年来在实验小鼠中被认为是由明显自发性肾病引起的肾脏疾病，是由一种新发现的名为小鼠肾细小病毒（MKPV）的病毒引起的。该病毒似乎在鼠群中广泛存在，因为目前的诊断工具无法检测到它，其发现为理解肾小管间质性纤维化的病理学提供了新的机会。