Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Virol J. 2021 Oct 24;18(1):210. doi: 10.1186/s12985-021-01677-y.
In line with the Latin expression "sed parva forti" meaning "small but mighty," the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramatically increased the identification of novel parvoviruses in both diseased and healthy individuals. While some of these discoveries have solved etiologic mysteries of well-described diseases in animals, many of the newly discovered parvoviruses appear to cause mild or no disease, or disease associations remain to be established. With the increased use of animal parvoviruses as vectors for gene therapy and oncolytic treatments in humans, it becomes all the more important to understand the diversity, pathogenic potential, and evolution of this diverse family of viruses. In this review, we discuss parvoviruses infecting vertebrate animals, with a special focus on pathogens of veterinary significance and viruses discovered within the last four years.
与拉丁语表达“sed parva forti”（意为“小而强大”）一致，细小病毒科包含许多已知的最小病毒，其中一些导致致命或使人虚弱的感染。近年来，宏基因组病毒发现技术的进步极大地增加了在患病和健康个体中新型细小病毒的鉴定。虽然这些发现中的一些解决了动物中描述良好疾病的病因之谜，但许多新发现的细小病毒似乎导致轻度或无疾病，或者疾病关联仍有待建立。随着动物细小病毒作为人类基因治疗和溶瘤治疗载体的使用增加，了解这个多样化病毒家族的多样性、致病潜力和进化变得更加重要。在这篇综述中，我们讨论了感染脊椎动物的细小病毒，特别关注兽医重要病原体和在过去四年中发现的病毒。
