Admon R, Vaisvaser S, Erlich N, Lin T, Shapira-Lichter I, Fruchter E, Gazit T, Hendler T
Department of Psychology, University of Haifa, Haifa, 3498838, Israel.
Sagol Brain Institute, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, 64239, Israel.
Biol Psychol. 2018 Nov;139:17-24. doi: 10.1016/j.biopsycho.2018.09.014. Epub 2018 Oct 2.
Prior research on the interaction between emotion and episodic memory established that negatively charged events are better remembered compared to neutral events (i.e. enhanced remembrance), as well as that a priori neutral cues that were present in the environment during a negative event can attain aversive meaning by themselves (i.e. acquired negativity). Improved understanding the neural mechanisms that mediate enhanced remembrance of negative episodes and acquired negativity of related neutral cues may carry substantial clinical relevance, particularly in the context of posttraumatic pathophysiology. In order to address this point forty-nine healthy participants completed a novel fMRI task that involve the presentation of neutral pictures before and after a series of short neutral and aversive video-clips from which the neutral pictures were originally extracted, and a subsequent presentation of these pictures as cues for clip recall [termed, Picture-Clip-Picture-Recall (PCPR) task]. Behavioral results indicate that aversive clips were indeed better remembered compared to neutral clips (i.e. enhanced remembrance of negative episode) and that a priori neutral pictures that appeared in aversive clips were rated more negatively after relative to before the exposure to the aversive clips (i.e. acquired negativity of related neutral cues). Whole-brain fMRI analysis revealed that increased amygdala activation in response to pictures when presented as cues for clip recall predicted successful clip remembrance, particularly remembrance of aversive clips. This amygdala activation was also correlated with the magnitude of acquired negativity of the cues following their appearance in aversive clips. Taken together our findings implicate the PCPR as a novel, naturalistic, framework for investigating the neural interface of emotional episodic memory, while highlighting the role of the amygdala in enhanced remembrance of negative episodes and acquired negativity of related neutral cues. Clinical implications are discussed.
先前关于情绪与情景记忆相互作用的研究表明，与中性事件相比，带有负性情绪的事件能被更好地记住（即记忆增强），并且在负性事件发生时出现在环境中的先验中性线索自身也能获得厌恶意义（即习得性负性）。更好地理解介导负性事件记忆增强和相关中性线索习得性负性的神经机制可能具有重要的临床意义，尤其是在创伤后病理生理学背景下。为了解决这一问题，49名健康参与者完成了一项新颖的功能磁共振成像（fMRI）任务，该任务包括在一系列短的中性和厌恶视频片段前后呈现中性图片（这些中性图片最初是从视频片段中提取的），随后将这些图片作为线索用于片段回忆[称为图片 - 片段 - 图片 - 回忆（PCPR）任务]。行为结果表明，与中性片段相比，厌恶片段确实能被更好地记住（即负性事件的记忆增强），并且出现在厌恶片段中的先验中性图片在接触厌恶片段后相对于接触前被评为更具负性（即相关中性线索的习得性负性）。全脑fMRI分析显示，当图片作为片段回忆线索呈现时，杏仁核激活增加预示着片段回忆成功，尤其是厌恶片段的回忆。这种杏仁核激活也与线索在厌恶片段中出现后习得性负性的程度相关。综合来看，我们的研究结果表明PCPR是一种用于研究情绪情景记忆神经界面的新颖、自然主义的框架，同时突出了杏仁核在负性事件记忆增强和相关中性线索习得性负性中的作用。讨论了其临床意义。
