Liu Chao, Liang Kun, Jiang Zhengxuan, Tao Liming
Department of Ophthalmology, the Second Hospital Affiliated to Anhui Medical University, Hefei, Anhui.
Department of Ophthalmology, the First Affiliated Hospital of Bengbu Medical College, Bengbu PR China.
Medicine (Baltimore). 2018 Oct;97(40):e12572. doi: 10.1097/MD.0000000000012572.
o assess the efficacy of sex hormone therapy in the treatment of dry eye syndrome in postmenopausal women.The following electronic databases were searched without language restrictions: PubMed, Embase, Cochrane, and the Chinese Biomedical Database. Two reviewers collected all the literature, which was searched for relevance in English and Chinese from January 1990 to July 2017. Both of the reviewers screened documents independently, identifying the studies that met the inclusion criteria. Then, the included studies were evaluated, and the data were extracted and conversed dependently. Finally, Review Manager 5.3 (offered by the Cochrane collaboration) was used to complete the meta-analysis. An integrated mean difference (MD) with its corresponding 95% confidence interval (CI) was calculated.A total of 358 patients with dry eye were enrolled in 7 randomized controlled trials (RCTs). We observed statistically significant improvements in the Schirmer's test scores (MD, 2.06; 95% CI, 0.74-4.46; I = 97%; P = .006) after sex hormone treatment. However, the scores for tear breakup time (TBUT) (MD, 1.28; 95% CI, -1.03 to 4.68; I = 99%; P = .21) and the ocular comfort index (OCI) (MD, -1.12; 95% CI, -4.42 to 1.98; I = 95%; P = .48) were not improved.This meta-analysis of 7 RCTs suggests that sex hormone therapy may be associated with better Schirmer's test scores. However, no significant differences were detected in the TBUT and OCI test scores. Consequently, sex hormone therapy has a potentially useful role in the effective management of postmenopausal women with dry eye syndrome.
本研究的目的是评估性激素疗法治疗绝经后女性干眼症的疗效。我们对以下无语言限制的电子数据库进行了检索：PubMed、Embase、Cochrane和中国生物医学数据库。两名综述员收集了所有文献，检索了1990年1月至2017年7月期间的英文和中文相关文献。两名综述员独立筛选文献，确定符合纳入标准的研究。然后，对纳入的研究进行评估，并独立提取和转换数据。最后，使用Review Manager 5.3（由Cochrane协作网提供）完成荟萃分析。计算了合并平均差（MD）及其相应的95%置信区间（CI）。
共有358例干眼症患者纳入了7项随机对照试验（RCT）。我们观察到性激素治疗后泪液分泌试验（Schirmer试验）评分有统计学意义的改善（MD，2.06；95%CI，0.74 - 4.46；I = 97%；P = .006）。然而，泪膜破裂时间（TBUT）评分（MD，1.28；95%CI， - 1.03至4.68；I = 99%；P = .21）和眼部舒适度指数（OCI）（MD， - 1.12；95%CI， - 4.42至1.98；I = 95%；P = .48）没有改善。
这项对7项RCT的荟萃分析表明，性激素疗法可能与更好的Schirmer试验评分相关。然而，在TBUT和OCI试验评分中未检测到显著差异。因此，性激素疗法在有效管理绝经后女性干眼症方面可能具有有益作用。
