Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Am J Gastroenterol. 2018 Oct;113(10):1435-1436. doi: 10.1038/s41395-018-0260-z. Epub 2018 Oct 5.
: There are strong associations between candidate genetic polymorphisms associated with intrahepatocyte lipid droplet accumulation and the development of cirrhosis, via a common sequence in which lipid accumulation is followed by chronic inflammatory injury and fibrogenesis. Hepatocellular carcinoma (HCC) has also been linked to genetic polymorphisms associated with intracellular lipid trafficking, although, as shown in the present study, not all the candidate polymorphisms implicated in fibrogenesis are also tied to HCC. Genetic analysis may identify at-risk persons who would most benefit from modifying life-style factors linked to cirrhosis and HCC, and also persons most likely to benefit from HCC surveillance.
: 与肝细胞内脂滴蓄积相关的候选基因多态性与肝硬化的发生之间存在密切关联，其发生机制涉及一个共同的序列，即脂滴蓄积后发生慢性炎症损伤和纤维化。肝细胞癌 (HCC) 也与与细胞内脂质转运相关的基因多态性相关，尽管如本研究所示，并非所有与纤维化相关的候选多态性也与 HCC 相关。遗传分析可能会识别出处于危险中的人群，这些人最有可能从与肝硬化和 HCC 相关的生活方式因素的改变中受益，也最有可能从 HCC 监测中受益。
