Modarres Parastoo, Tavalaee Marziyeh, Ghaedi Kamran, Nasr-Esfahani Mohammad Hossein
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.
Int J Fertil Steril. 2019 Jan;12(4):273-277. doi: 10.22074/ijfs.2019.5561. Epub 2018 Oct 2.
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phenomenon referred to globozoospermia.
顶体在受精过程中发挥着不可或缺的作用，圆头精子症患者缺乏顶体导致受精（体外受精）失败以及胞浆内单精子注射（ICSI）后卵母细胞激活失败。顶体生物发生涉及多种过程、细胞器和结构，包括反式高尔基体网络（TGN）、顶体板和细胞运输。本综述旨在解释参与这一过程的相关信号和分子的作用，并描述它们以突变、缺失和基因敲除模型的形式缺失如何导致圆头精子症现象。
