Stein Carolina S, de Carvalho José A M, Duarte Marta M M F, da Cruz Ivana B M, Premaor Melissa O, Comim Fabio V, Moretto Maria B, Moresco Rafael N
Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS, Brazil; Pharmaceutical Sciences Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS, Brazil; University Hospital, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Mutat Res. 2018 Sep;811:27-30. doi: 10.1016/j.mrfmmm.2018.09.001. Epub 2018 Sep 22.
Uric acid presents different roles in an organism, since it can act as an antioxidant or a pro-oxidant molecule. High serum uric acid levels may cause damage to several structures, including nucleic acids and its components. Therefore, in this study the association between increased serum uric acid concentrations and oxidation of nucleosides was investigated by assessment of urinary 8-hydroxydeoxyguanosine (8-OHdG) in patients with type 2 diabetes (T2D) and in healthy individuals. Urinary 8-OHdG and biochemical parameters were assessed in 61 patients who were initially grouped into 2 groups based on the median serum uric acid levels (<5.3 mg/dL and ≥5.3 mg/dL). Urinary 8-OHdG was higher in patients with T2D and serum uric acid levels ≥5.3 mg/dL, when compared with the patients with serum uric acid levels <5.3 mg/dL; however, co-occurrence of high serum uric acid with high urinary 8-OHdG was not observed in healthy individuals. A significant positive correlation between 8-OHdG and uric acid (r = 0.40, P < 0.01) was observed in patients with T2D. High serum uric acid levels were associated with high urinary 8-OHdG levels in patients with T2D, and this association was independent of gender, hypertension, body mass index, and serum creatinine.
尿酸在生物体中发挥着不同的作用，因为它既可以作为抗氧化分子，也可以作为促氧化分子。高血清尿酸水平可能会对包括核酸及其成分在内的多种结构造成损害。因此，在本研究中，通过评估2型糖尿病（T2D）患者和健康个体的尿8-羟基脱氧鸟苷（8-OHdG），研究了血清尿酸浓度升高与核苷氧化之间的关联。对61例患者的尿8-OHdG和生化参数进行了评估，这些患者最初根据血清尿酸水平中位数（<5.3mg/dL和≥5.3mg/dL）分为两组。与血清尿酸水平<5.3mg/dL的患者相比，T2D患者且血清尿酸水平≥5.3mg/dL时尿8-OHdG更高；然而，在健康个体中未观察到高血清尿酸与高尿8-OHdG同时出现的情况。在T2D患者中观察到8-OHdG与尿酸之间存在显著正相关（r = 0.40，P < 0.01）。T2D患者中高血清尿酸水平与高尿8-OHdG水平相关，且这种关联独立于性别、高血压、体重指数和血清肌酐。
