Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Mol Divers. 2019 May;23(2):509-526. doi: 10.1007/s11030-018-9878-4. Epub 2018 Oct 6.
Iron plays a vital role in several cellular functions due to its unique physiochemical properties. Iron concentration increases in the brain with age due to multiple factors. Excessive amount of iron can lead to formation of reactive oxygen species. Neurodegenerative disorders are characterized by iron supplemented increase in oxidative stress and cellular damage. There is an urgent need of novel therapies which should not only provide symptomatic relief but also be able to modulate iron accumulation in the brain. Therefore, the development of novel iron chelators as neuroprotective agents for the treatment of neurodegeneration is an emerging trend. Several iron chelators including 8-hydroxyquinoline derivatives, dopaminergic agonists and natural products are under preclinical and clinical investigations for the treatment of neurodegenerative disorders.
铁因其独特的物理化学性质，在多种细胞功能中起着至关重要的作用。由于多种因素，铁浓度会随着年龄的增长在大脑中增加。过多的铁会导致活性氧的形成。神经退行性疾病的特征是铁补充增加氧化应激和细胞损伤。因此，我们急需新的治疗方法，这些方法不仅要能提供症状缓解，还要能够调节大脑中的铁积累。因此，开发新型铁螯合剂作为神经保护剂来治疗神经退行性疾病是一种新兴趋势。几种铁螯合剂，包括 8-羟基喹啉衍生物、多巴胺激动剂和天然产物，正在进行临床前和临床研究，以治疗神经退行性疾病。
