Keagy Carolyn D
Kaiser Permanente, 1795 Second Street, Berkeley, CA, 94710, USA.
Int Urogynecol J. 2019 Mar;30(3):363-370. doi: 10.1007/s00192-018-3771-7. Epub 2018 Oct 6.
The topic of interstitial cystitis (IC), also known as painful bladder syndrome (PBS), and folate/one carbon metabolism has previously been unaddressed in research. This narrative review highlights a potential connection for those with mast cell-related IC and histamine-mediated pain that is explored through four conceptual sections. The first section focuses on the nature of mast cell involvement and histamine-mediated pain in some interstitial cystitis patients. The second section reviews the literature on folate status in wider allergic conditions. The third section addresses the role of folate and methylation in general in histamine excretion. Finally, folate metabolism and vascular function are addressed because of the vascular abnormalities present in some IC bladders.
间质性膀胱炎（IC），也称为膀胱疼痛综合征（PBS），与叶酸/一碳代谢的主题此前在研究中未被涉及。本叙述性综述强调了肥大细胞相关的间质性膀胱炎患者与组胺介导的疼痛之间的潜在联系，并通过四个概念部分进行探讨。第一部分聚焦于一些间质性膀胱炎患者中肥大细胞参与的性质和组胺介导的疼痛。第二部分回顾了关于更广泛过敏状况下叶酸状态的文献。第三部分阐述了叶酸和甲基化在组胺排泄中的一般作用。最后，由于一些间质性膀胱炎患者的膀胱存在血管异常，因此探讨了叶酸代谢与血管功能。
