一名同时患有肠易激综合征和间质性膀胱炎的患者中肥大细胞和P物质阳性神经的参与情况。

Mast cell and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis.

作者信息

Pang X, Boucher W, Triadafilopoulos G, Sant G R, Theoharides T C

机构信息

Department of Pharmacology, Experimental Therapeutics, and Urology, Tufts University School of Medicine-New England Medical Center, Boston 02111, USA.

出版信息

Urology. 1996 Mar;47(3):436-8. doi: 10.1016/S0090-4295(99)80469-5.

DOI:10.1016/S0090-4295(99)80469-5

PMID:8633418

Abstract

Many patients with interstitial cystitis (IC) also have irritable bowel syndrome (IBS), both of which occur overwhelmingly in women, are characterized by pain, and worsen under stress. Bladder and colon biopsies of a female patient with both IC and IBS were evaluated immunohistochemically. There were 40 +/- 10 mast cells (MC)/mm2 (normal, less than 10) in the bladder, which were degranulated. The colon contained 148 +/- 11 MC/mm2 (normal, less than 50), mostly close to numerous substance P (SP)-positive nerves. Histamine, methylhistamine, and the unique MC enzyme tryptase were evaluated in 24-hour urine during two flare-ups. These results may help explain the concurrent presentation and the painful nature of these syndromes.

摘要

许多间质性膀胱炎（IC）患者同时患有肠易激综合征（IBS），这两种疾病在女性中极为常见，均以疼痛为特征，且在压力下会加重。对一名同时患有IC和IBS的女性患者的膀胱和结肠活检组织进行了免疫组织化学评估。膀胱中每平方毫米有40±10个肥大细胞（MC）（正常情况下少于10个），且这些肥大细胞已脱颗粒。结肠中每平方毫米含有148±11个MC（正常情况下少于50个），大多数靠近大量P物质（SP）阳性神经。在两次病情发作期间对24小时尿液中的组胺、甲基组胺以及独特的MC酶类胰蛋白酶进行了评估。这些结果可能有助于解释这些综合征的同时出现及其疼痛性质。