Chen L, Zhang M, Li C, Tao L, Wang S Y, Zhou L
Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.
Department of Pathology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Sep 7;53(9):684-687. doi: 10.3760/cma.j.issn.1673-0860.2018.09.009.
To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66.5 years old; 8 patients with adenoid cystic carcinoma, 4 with mucoepidermoid carcinoma and 2 with adenocarcinoma; supraglottic, glottic and 4 subglottic malignancies respectively accounting for 5, 5 and 4 cases; 8 cases treated with surgery, 5 with surgery and postoperative radiotherapy and/or chemotherapy, and 1 with radiotherapy alone. The 14 patients showed a three-year overall survival rate of 50.0% and a five-year overall survival rate of 42.9%, respectively in contrast with the rates of 67.1% and 59.8% in SEER database. The malignant salivary gland tumor of the larynx is rare and it is difficult to be diagnosed early. It is more likely to occour local recurrence and distant metastasis. Extensive surgical resection with postoperative radiotherapy is advocated.
评估喉恶性涎腺肿瘤的临床特征、治疗方法及预后。回顾性分析2003年至2014年间在我院诊断并治疗的14例喉恶性涎腺肿瘤患者，并与美国监测、流行病学和最终结果（SEER）数据库中的62例患者进行生存率比较。结果我院14例患者中，男性9例，女性5例，中位年龄66.5岁；腺样囊性癌8例，黏液表皮样癌4例，腺癌2例；声门上型、声门型和声门下型恶性肿瘤分别为5例、5例和4例；8例行手术治疗，5例行手术及术后放疗和/或化疗，1例仅行放疗。14例患者的三年总生存率和五年总生存率分别为50.0%和42.9%，而SEER数据库中的这两个比率分别为67.1%和59.8%。喉恶性涎腺肿瘤罕见，早期难以诊断，更容易发生局部复发和远处转移。主张行广泛手术切除并术后放疗。
