Cohen J, Guillamondegui O M, Batsakis J G, Medina J E
Am J Surg. 1985 Oct;150(4):513-8. doi: 10.1016/0002-9610(85)90166-7.
Minor salivary gland carcinomas of the larynx are rare and few large series have been reported from a single institution. Eighteen patients were treated for this disease at M.D. Anderson Hospital between 1944 and 1982. Of these, 8 patients had adenoid cystic carcinoma and 10 had poorly differentiated adenocarcinoma. Characteristically these tumors presented as predominantly submucosal masses in the supraglottic or subglottic regions. Surgery was the primary treatment modality used in most cases. The average 2 and 5 year survival rates for patients with this disease were 70.6 percent and 42.8 percent, respectively. Although the 5 year survival rates were comparable between the adenocarcinoma and cystic carcinoma groups, adenocarcinoma was a more rapidly lethal disease than adenoid cystic carcinoma. Salvage after recurrence was seldom possible, although local and regional control could usually be achieved. Distant metastases remain the principal cause of treatment failure.
喉小涎腺癌十分罕见，单一机构报道的大宗病例很少。1944年至1982年间，18例患者在MD安德森癌症中心接受了该病的治疗。其中，8例为腺样囊性癌，10例为低分化腺癌。这些肿瘤的特征性表现为主要位于声门上或声门下区域的黏膜下肿块。大多数病例的主要治疗方式为手术。该病患者的平均2年和5年生存率分别为70.6%和42.8%。虽然腺癌组和囊性癌组的5年生存率相当，但腺癌比腺样囊性癌的致死速度更快。复发后很少能挽救，尽管通常可以实现局部和区域控制。远处转移仍然是治疗失败的主要原因。
