Jiang T, Yao X A, Wei B B, Chang H
Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Zhonghua Nei Ke Za Zhi. 2018 Oct 1;57(10):753-755. doi: 10.3760/cma.j.issn.0578-1426.2018.10.011.
To explore the impact of gender on presentation of primary hyperparathyroidism (PHPT), clinical data of 150 histopathologically proven PHPT patients were collected and retrospectively analyzed. Most of the patients (72.0%) were parathyroid adenoma (PA), and 9.3% of them were parathyroid carcinoma (PC). In PA patients, albumin-corrected serum calcium levels (TASC) were lower in women than in men [ (2.84±0.28) mmol/L vs. (3.03±0.34) mmol/L, 0.006]. In all PHPT subjects, serum urea nitrogen, creatinine, uric acid levels were lower in women than in men. Bone pain was more frequent in women over 50 years old than in men (52.33% vs.29.17%, 0.045). The incidence of PC was higher in men than in women (20.59% vs. 6.03%, 0.010). In conclusion, there are gender differences in the clinical presentation of PHPT. TASC was high in men with PA compared to women with PA. Bone pain was more common in the woman patients over 50 years old, and PC was more common in men.
为探讨性别对原发性甲状旁腺功能亢进症（PHPT）临床表现的影响，收集了150例经组织病理学证实的PHPT患者的临床资料并进行回顾性分析。大多数患者（72.0%）为甲状旁腺腺瘤（PA），其中9.3%为甲状旁腺癌（PC）。在PA患者中，女性的白蛋白校正血清钙水平（TASC）低于男性[（2.84±0.28）mmol/L对（3.03±0.34）mmol/L，P = 0.006]。在所有PHPT患者中，女性的血清尿素氮、肌酐、尿酸水平均低于男性。50岁以上女性的骨痛发生率高于男性（52.33%对29.17%，P = 0.045）。男性的PC发病率高于女性（20.59%对6.03%，P = 0.010）。总之，PHPT的临床表现存在性别差异。与PA女性患者相比，PA男性患者的TASC较高。50岁以上女性患者骨痛更为常见，而PC在男性中更为常见。
