Arnold Renée J G, Han Yun, Balakrishnan Rajesh, Layton Andrew, Lok Charmaine E, Glickman Marc, Rajan Dheeraj K
Navigant Consulting, San Francisco, California; Icahn School of Medicine at Mount Sinai, New York, New York.
University of Michigan, Ann Arbor, Michigan.
J Vasc Interv Radiol. 2018 Nov;29(11):1558-1566.e2. doi: 10.1016/j.jvir.2018.05.014. Epub 2018 Oct 5.
To compare: (i) rate of arteriovenous fistula (AVF) interventions in both incident and prevalent end-stage kidney disease patients; (ii) their associated costs; and (iii) intervention-free survival between patients with surgical hemodialysis arteriovenous fistula (SAVF) versus those with an endovascularly created fistula (endoAVF).
Data from the United States Renal Data System (USRDS) were abstracted to determine the rate of AVF interventions performed in the first year and associated costs (based on Medicare payment rates) for SAVFs created from 2011 to 2013 in the incident and prevalent patient cohorts. Comparative data for endoAVF were obtained from the Novel Endovascular Access Trial (NEAT). Event rates, intervention-free survival, and costs were compared between endoAVF and SAVF cohorts after 1:1 propensity score (PS) matching.
In the matched incident patients, the event rate was 0.74 per patient-year (PY) for endoAVF versus 7.22/PY for SAVF (P < .0001), with a difference in expenditures of $16,494. Similarly, in matched prevalent patients the event rate was 0.46/PY for endoAVF vs 4.10/PY for SAVF (P < .0001), resulting in a cost difference of $13,389. Time-to-event analysis showed that at 1 year, 70% of endoAVF patients experienced freedom from intervention versus only 18% of SAVF patients for incident patients; these numbers were 62% and 18% for endoAVF and SAVF prevalent patients, respectively (P < .0001 for both).
Both incident and prevalent patients with endoAVF required fewer interventions and had lower costs within the first year compared with matched patients with SAVF.
比较:(i)新发和已患终末期肾病患者的动静脉内瘘(AVF)干预率;(ii)其相关成本;以及(iii)接受外科血液透析动静脉内瘘(SAVF)的患者与接受血管腔内造瘘术(endoAVF)的患者之间的无干预生存期。
提取美国肾脏数据系统(USRDS)的数据,以确定2011年至2013年在新发和已患患者队列中创建的SAVF在第一年的AVF干预率及相关成本(基于医疗保险支付率)。endoAVF的比较数据来自新型血管腔内通路试验(NEAT)。在进行1:1倾向评分(PS)匹配后,比较endoAVF和SAVF队列的事件发生率、无干预生存期和成本。
在匹配的新发患者中,endoAVF的事件发生率为每患者年(PY)0.74,而SAVF为7.22/PY(P <.0001),支出差异为16,494美元。同样,在匹配的已患患者中,endoAVF的事件发生率为0.46/PY,而SAVF为4.10/PY(P <.0001),成本差异为13,389美元。事件发生时间分析显示,在1年时,新发患者中70%的endoAVF患者无干预,而SAVF患者仅为18%;对于已患患者,endoAVF和SAVF患者的这一数字分别为62%和18%(两者P均<.0001)。
与匹配的SAVF患者相比,endoAVF的新发和已患患者在第一年内所需的干预较少,成本较低。