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对黏液瘤病毒中一个基因的定位与测序,该基因与那些编码表皮生长因子和转化生长因子α的基因相关。

Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha.

作者信息

Upton C, Macen J L, McFadden G

出版信息

J Virol. 1987 Apr;61(4):1271-5. doi: 10.1128/JVI.61.4.1271-1275.1987.

Abstract

Myxoma virus, a Leporipoxvirus and agent of myxomatosis, was shown to possess a gene with the potential to encode an epidermal growth factorlike factor. Its relationship to other members of this family, including the poxvirus growth factors from Shope fibroma virus and vaccinia virus, was analyzed. Alignment of DNA sequences and related open reading frames of myxoma virus and Shope fibroma virus indicated colinearity of genes between these poxviruses.

摘要

黏液瘤病毒是一种兔痘病毒,也是黏液瘤病的病原体,它被证明拥有一个有潜力编码类表皮生长因子的基因。分析了它与该家族其他成员的关系,包括来自肖普纤维瘤病毒和痘苗病毒的痘病毒生长因子。黏液瘤病毒和肖普纤维瘤病毒的DNA序列及相关开放阅读框的比对表明,这些痘病毒之间的基因具有共线性。

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