Jia Jia, Cheng Jian, Wang Cheng, Zhen Xuechu
Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Institute of Neuroscience, Soochow University, Suzhou, China.
Front Cell Neurosci. 2018 Sep 20;12:314. doi: 10.3389/fncel.2018.00314. eCollection 2018.
A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astrocytes express Sig-1Rs. Activation of Sig-1Rs is known to elicit potent neuroprotective effects and promote neuronal survival via multiple mechanisms, including promoting mitochondrial functions, decreasing oxidative stress and regulating neuroimmnological functions. In this review article, we focus on the emerging role of Sig-1Rs in regulating neuroinflammation and discuss the recent advances on the Sig-1R-modulating neuroinflammation in the pathophysiology and therapy of neurodegenerative disorders.
大量证据表明，σ-1受体（Sig-1R）是多种神经精神疾病的重要药物靶点。Sig-1R在中枢神经系统（CNS）中高度富集。除神经元外，脑小胶质细胞和星形胶质细胞均表达Sig-1R。已知激活Sig-1R可通过多种机制产生强大的神经保护作用并促进神经元存活，包括促进线粒体功能、降低氧化应激和调节神经免疫功能。在这篇综述文章中，我们重点关注Sig-1R在调节神经炎症中的新作用，并讨论Sig-1R调节神经炎症在神经退行性疾病病理生理学和治疗中的最新进展。
