Sparks Jackson T, Botsko Gina, Swale Daniel R, Boland Linda M, Patel Shriraj S, Dickens Joseph C
Biology Department, High Point University, High Point, NC, United States.
Department of Entomology, Louisiana State University AgCenter, Baton Rouge, LA, United States.
Front Physiol. 2018 Sep 20;9:1309. doi: 10.3389/fphys.2018.01309. eCollection 2018.
Mosquitoes use chemical cues to modulate important behaviors such as feeding, mating, and egg laying. The primary chemosensory organs comprising the paired antennae, maxillary palps and labial palps are adorned with porous sensilla that house primary sensory neurons. Dendrites of these neurons provide an interface between the chemical environment and higher order neuronal processing. Diverse proteins located on outer membranes interact with chemicals, ions, and soluble proteins outside the cell and within the lumen of sensilla. Here, we review the repertoire of chemosensory receptors and other membrane proteins involved in transduction and discuss the outlook for their functional characterization. We also provide a brief overview of select ion channels, their role in mammalian taste, and potential involvement in mosquito taste. These chemosensory proteins represent targets for the disruption of harmful biting behavior and disease transmission by mosquito vectors.
蚊子利用化学信号来调节诸如觅食、交配和产卵等重要行为。主要的化学感应器官包括成对的触角、下颚须和唇须，这些器官上布满了多孔的感觉器，其中容纳着初级感觉神经元。这些神经元的树突在化学环境和高级神经元处理之间提供了一个界面。位于外膜上的多种蛋白质与细胞外、感觉器管腔内的化学物质、离子和可溶性蛋白质相互作用。在这里，我们综述了参与信号转导的化学感应受体和其他膜蛋白的种类，并讨论了它们功能表征的前景。我们还简要概述了选定的离子通道、它们在哺乳动物味觉中的作用以及在蚊子味觉中的潜在作用。这些化学感应蛋白是破坏蚊子媒介有害叮咬行为和疾病传播的靶点。
