Tsuchiya E, Oh S, Kitagawa T, Matsubara T, Nakagawa K, Kinoshita I, Sugano H
Gan No Rinsho. 1987 Jan;33(1):27-34.
The influence of smoking on the development of pulmonary carcinoma of various histological subtypes was analyzed in 244 primary and 84 metastatic lung cancer patients. The new WHO classification was used for histological diagnosis. The relative risk was calculated by the odds ratio. It was found that all the squamous, small-and large-cell carcinomas were derived from smokers with relative risks of 27.8, 7.5 and 5.6, respectively. On the other hand, adenocarcinoma had very little, if any, relationship with smoking, the relative risk being 1.5 in men and 1.3 in women. The high-risk group for squamous cell carcinoma in men was defined with a regression line of y (duration of smoking) on x (number of cigarettes per day) as y = -0.24 x + 48.6.
在244例原发性肺癌患者和84例转移性肺癌患者中，分析了吸烟对不同组织学亚型肺癌发生的影响。组织学诊断采用世界卫生组织新分类法。相对风险通过比值比计算得出。结果发现，所有鳞状细胞癌、小细胞癌和大细胞癌均来源于吸烟者，相对风险分别为27.8、7.5和5.6。另一方面，腺癌与吸烟的关系极小（如果有关系的话），男性相对风险为1.5，女性为1.3。男性鳞状细胞癌的高危组通过以y（吸烟持续时间）对x（每日吸烟支数）的回归线定义为y = -0.24x + 48.6。
