Kuo Ching-Te, Wang Jong-Yueh, Wo Andrew M, Chen Benjamin P C, Lee Hsinyu
Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Department of Life Science, National Taiwan University, Taipei 10617, Taiwan, R.O.C.
Adv Biosyst. 2017 May;1(5). doi: 10.1002/adbi.201700048. Epub 2017 Apr 24.
Engineered materials have been employed as versatile tools to explore the fundamental cell biology/drug development as well as to approach the intelligent device, thereby becoming the key components in modern technology. Herein, a ParaStamp technique has been revealed to possess applications for cell patterning, drug screening, and rewritable functional patterning. The ParaStamp includes a micropatterned PDMS master and a liquid-phased paraffin oil generated at high temperature, which can transfer the patterned paramembrane onto varied material surfaces, such as glass, polystyrene, and flexible foil. This technique is simple and cost-effective to meet the high-throughput requirement for industries. Taken together, our findings herein should have general insights in cell biology, biodetection, and development of smart hydrophobic surface.
工程材料已被用作探索细胞基础生物学/药物开发以及实现智能设备的多功能工具，从而成为现代技术的关键组成部分。在此，已揭示一种ParaStamp技术可用于细胞图案化、药物筛选和可重写功能图案化。ParaStamp包括一个微图案化的聚二甲基硅氧烷（PDMS）母版和高温产生的液相石蜡油，它可以将图案化的类膜转移到各种材料表面，如玻璃、聚苯乙烯和柔性箔片上。该技术简单且成本效益高，能够满足工业的高通量需求。综上所述，我们在此的发现应该对细胞生物学、生物检测和智能疏水表面的开发具有普遍的启示。
