Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Karlsruhe Institute of Technology, Institute of Microstructure Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Adv Mater. 2015 Sep 16;27(35):5217-22. doi: 10.1002/adma.201502115. Epub 2015 Aug 10.
A droplet-array (DA) sandwich chip is a miniaturized platform for cell-based high-throughput screening. It is based on sandwiching of a glass slide with a preprinted library and a superhydrophobic-superhydrophilic pattern, which consists of thousands of simultaneously formed microdroplets containing cells. The DA sandwich chip allows for one-step cell seeding, simultaneous initiation of screening, and 1000 times less reagent consumption than a regular 96-well plate.
液滴阵列(DA)夹层芯片是一种基于夹层玻璃载玻片与预印文库和超疏水-超亲水图案的细胞高通量筛选的微型化平台,它由数千个同时形成的包含细胞的微滴组成。DA 夹层芯片允许一步法细胞接种,同时启动筛选,与常规 96 孔板相比,试剂消耗量减少 1000 倍。