Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Shioiri Mental Clinic, Yokosuka, Japan.
Psychogeriatrics. 2019 Mar;19(2):111-116. doi: 10.1111/psyg.12373. Epub 2018 Oct 8.
This was an exploratory study to examine the factors influencing nursing home placement (NHP) in Japan.
For this analysis, 633 patients were selected. The data were collected from the clinical records of each patient. A log-rank test was performed. The time from the patient's first visit to the clinic until the nursing home placement was the independent variable. Age (<80 or ≥80 years), biological sex (male or female), Clinical Dementia Rating scale (CDR) score (overall index 0.5, 1, 2, or 3), living situation (living alone or with someone), and voxel-based specific regional analysis systems for Alzheimer's disease Z-score (<2 or ≥2) were the dependent variables. Survival curves were obtained by using the Kaplan-Meier estimate. After the log-rank test, we conducted a Cox proportional hazards regression analysis.
The results of log-rank test indicated that all the variables could significantly influence time to NHP. Cox proportional hazards regression analysis suggested that CDR 3 exhibited the highest hazard ratio and Z-score showed the lowest hazard ratio. There were significant differences in age, sex, CDR 2, CDR 3, and living situation.
The results indicated that the voxel-based specific regional analysis systems for Alzheimer's disease Z-score is unlikely to influence NHP. This may suggest that even if the atrophy in the medial temporal lobe is rather progressed, patients can remain living at their own home with protective factors. Future studies need to investigate the risk and protective factors of time to NHP by combining the variables.
本研究旨在探讨影响日本养老院安置(NHP)的因素。
本分析选取了 633 名患者。数据来自每位患者的临床记录。采用对数秩检验。从患者首次就诊到养老院安置的时间为自变量。年龄(<80 岁或≥80 岁)、生物性别(男或女)、临床痴呆评定量表(CDR)评分(总指数 0.5、1、2 或 3)、居住情况(独居或与他人同住)和阿尔茨海默病基于体素的特定区域分析系统 Z 分数(<2 或≥2)为因变量。采用 Kaplan-Meier 估计获得生存曲线。对数秩检验后,进行 Cox 比例风险回归分析。
对数秩检验结果表明,所有变量均能显著影响 NHP 时间。Cox 比例风险回归分析表明,CDR 3 表现出最高的风险比,Z 分数表现出最低的风险比。年龄、性别、CDR 2、CDR 3 和居住情况存在显著差异。
结果表明,阿尔茨海默病基于体素的特定区域分析系统 Z 分数不太可能影响 NHP。这可能表明,即使内侧颞叶萎缩较为严重,患者仍可在保护因素的作用下,继续在家中生活。未来的研究需要通过结合这些变量,探讨 NHP 时间的风险和保护因素。