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与年龄和性别匹配的对照组相比,新发痴呆病例的机构化情况:来自德国的5年随访研究

Institutionalization in incident dementia cases in comparison to age- and sex- matched controls: a 5-year follow-up from Germany.

作者信息

Schulze Jana, van den Bussche Hendrik, Kaduszkiewicz Hanna, Koller Daniela, Hoffmann Falk

机构信息

Division Health Economics, Health Policy and Outcomes Research, Centre for Social Policy Research, University of Bremen, Mary-Somerville-Straße 5, 28359, Bremen, Germany,

出版信息

Soc Psychiatry Psychiatr Epidemiol. 2015 Jan;50(1):143-51. doi: 10.1007/s00127-014-0911-3. Epub 2014 Jun 8.

Abstract

BACKGROUND

Dementia is a main reason for nursing home admission. Information on institutionalization is often based on studies of limited methodological quality. We aimed to analyze time until nursing home admission since first coding of dementia diagnosis and factors associated with institutionalization in incident dementia patients compared to non-demented controls.

METHODS

We analyzed claims data of a German Health insurance company including a cohort of 1,440 patients with a first diagnosis of dementia and 6,988 age- and sex-matched controls aged 65 years and older. The follow-up was up to 5 years. We used Kaplan-Meier analysis for examining time until nursing home admission and cox regression for estimating crude and adjusted Hazard ratios.

RESULTS

Dementia patients and controls were on average 78 years and about 55 % were males. The mean time to nursing home admission was 4.0 years in patients with dementia and 4.6 years for controls. After the 5-years observation-period 62.7 % (95 % CI 59.0-66.1) of dementia patients still lived in the community in comparison to 86.2 % (95 % CI 85.2-87.2) of controls. Cox regression models show that the risk for institutionalization is 3.45 (95 % CI 3.05-3.90) times higher in dementia patients in comparison to controls when adjusted for sex, age, and comorbidity.

CONCLUSIONS

Our analysis shows a significant influence of dementia on institutionalization in comparison to age- and sex-matched controls, especially in the youngest age groups. Hence, the results add substantial information on the disease progression of dementia and are, therefore, of great importance for health-care as well as long-term care planning.

摘要

背景

痴呆症是养老院入住的主要原因。关于机构化的信息通常基于方法学质量有限的研究。我们旨在分析自痴呆症诊断首次编码以来直至养老院入住的时间,以及与新发痴呆症患者相比,非痴呆症对照者机构化的相关因素。

方法

我们分析了一家德国健康保险公司的理赔数据,其中包括1440例首次诊断为痴呆症的患者队列以及6988例年龄和性别匹配的65岁及以上对照者。随访时间长达5年。我们使用Kaplan-Meier分析来检查直至养老院入住的时间,并使用Cox回归来估计粗风险比和调整后的风险比。

结果

痴呆症患者和对照者的平均年龄为78岁,约55%为男性。痴呆症患者入住养老院的平均时间为4.0年,对照者为4.6年。经过5年的观察期,62.7%(95%可信区间59.0 - 66.1)的痴呆症患者仍居住在社区,而对照者的这一比例为86.2%(95%可信区间85.2 - 87.2)。Cox回归模型显示,在调整性别、年龄和合并症后,痴呆症患者机构化的风险比对照者高3.45倍(95%可信区间3.05 - 3.90)。

结论

我们的分析表明,与年龄和性别匹配的对照者相比,痴呆症对机构化有显著影响,尤其是在最年轻的年龄组。因此,这些结果为痴呆症的疾病进展增添了大量信息,对医疗保健以及长期护理规划具有重要意义。

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