From the Department of Dermatology, Rutgers, Robert Wood Johnson Medical School, Somerset, New Jersey.
Arch Pathol Lab Med. 2019 Mar;143(3):326-329. doi: 10.5858/arpa.2018-0124-OA. Epub 2018 Oct 8.
CONTEXT.—: Histopathology is the current standard to diagnose skin disease. However, biopsy may not always be feasible, such as in patients with multiple nevi, a patient with a lesion on an aesthetically significant site, or in children. Recently, noninvasive techniques, including reflectance confocal microscopy (RCM), optical coherence tomography, and Raman spectroscopy, have enabled dermatologists to manage skin lesions in real time without the need for biopsy.
OBJECTIVE.—: To report the updated diagnostic accuracy of RCM for equivocal skin lesions.
DESIGN.—: In this study, we retrospectively reviewed our data of clinically suspicious lesions from 2010 to 2017 that were evaluated by RCM.
RESULTS.—: Our results showed an overall sensitivity of 98.2% and specificity of 99.8%.
CONCLUSIONS.—: In conclusion, RCM is a noninvasive real-time tool with the potential to diagnose skin lesions with high accuracy and without biopsy.
组织病理学是目前诊断皮肤疾病的标准。然而，活检并非总是可行，例如在有多发性痣的患者、病变位于美学重要部位的患者或儿童中。最近，非侵入性技术，包括反射共聚焦显微镜（RCM）、光相干断层扫描和拉曼光谱学，使皮肤科医生能够实时管理皮肤病变，而无需进行活检。
报告 RCM 对疑似皮肤病变的最新诊断准确性。
在这项研究中，我们回顾性地分析了 2010 年至 2017 年我们通过 RCM 评估的临床可疑病变的数据。
我们的结果显示整体敏感性为 98.2%，特异性为 99.8%。
总之，RCM 是一种非侵入性的实时工具，具有高准确性和无需活检即可诊断皮肤病变的潜力。
