Simmonds M A
Med Biol. 1986;64(6):301-11.
Electrophysiological and pharmacological evidence is summarized for the existence of an inhibitory receptor system operated by glycine and another two separate systems operated by gamma-aminobutyric acid (GABA) through GABA-A and GABA-B receptors, respectively. Claims for subclasses of GABA-A receptor are critically reviewed and found not-proven. A quantitative pharmacological profile of the GABA-A receptor and associated regulatory sites for picrotoxin, barbiturates and benzodiazepines on the dorsal funiculus of the rat cuneate nucleus is described. When compared with this profile and the pharmacological properties of the glycine receptor complex, the effects of taurine cannot be entirely explained by actions on these two receptor systems.
本文总结了电生理学和药理学证据，以证明存在由甘氨酸操纵的抑制性受体系统，以及另外两个分别由γ-氨基丁酸（GABA）通过GABA-A和GABA-B受体操纵的独立系统。对GABA-A受体亚类的说法进行了严格审查，发现未经证实。描述了大鼠楔束核背索上GABA-A受体以及印防己毒素、巴比妥类药物和苯二氮卓类药物相关调节位点的定量药理学特征。与该特征以及甘氨酸受体复合物的药理特性相比，牛磺酸的作用不能完全用对这两种受体系统的作用来解释。
