We Wei, Ding Li, Zheng Xiao-Li, Han Dong-Mei, Wang Zhi-Dong, Yan Hong-Ming, Wang Heng-Xiang
Department of Hematology, Chinese Air Force General Hospital, Beijing 100142,China.
Department of Hematology, Chinese Air Force General Hospital, Beijing 100142,China.E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Oct;26(5):1442-1446. doi: 10.7534/j.issn.1009-2137.2018.05.031.
To investigate the relationship between acute graft-versus-host disease and graft composition in patients with aplastic anemia(AA) after haploidentical hematopoietic stem cell transplantation.
Fifty-seven cases of AA after haploidentical hematopoietic stem cell transplantation were retrospectively analyzed. All the patients were divided into 2 groups according to whether presence or absence grade Ⅱ-Ⅳ aGVHD, the relationship between aGVHD and graft composition was analyzed by comparing the differences of graft components between the 2 groups.
Fourteen out of 57 patients had grade Ⅱ-Ⅳ aGVHD and the other 43 did not have grade Ⅱ-Ⅳ aGVHD. The mononuclear cells, CD3, CD4, CD8, NK cells, NKT cells, B cells and Treg cells were not significantly different between the 2 groups (P>0.05), the CD34 cell count in the patients with grade Ⅱ-Ⅳ aGVHD was 3.85（1.73-10.61）×10/kg, which was significantly lower than that without grade Ⅱ-ⅣaGVHD: 6.31（2.98-19.35）×10/kg (P<0.05).
The incidence of grade Ⅱ-Ⅳ aGVHD may be related with CD34 cell count in AA after haploidentical hematopoietic stem cell transplantation..
探讨单倍体造血干细胞移植后再生障碍性贫血（AA）患者急性移植物抗宿主病与移植物组成的关系。
回顾性分析57例单倍体造血干细胞移植后的AA患者。根据是否发生Ⅱ-Ⅳ级急性移植物抗宿主病（aGVHD）将所有患者分为2组，通过比较2组移植物成分的差异分析aGVHD与移植物组成的关系。
57例患者中14例发生Ⅱ-Ⅳ级aGVHD，43例未发生Ⅱ-Ⅳ级aGVHD。2组间单个核细胞、CD3、CD4、CD8、NK细胞、NKT细胞、B细胞和调节性T细胞差异无统计学意义（P>0.05），Ⅱ-Ⅳ级aGVHD患者的CD34细胞计数为3.85（1.73-10.61）×10/kg，显著低于未发生Ⅱ-Ⅳ级aGVHD患者的6.31（2.98-19.35）×10/kg（P<0.05）。
单倍体造血干细胞移植后AA患者Ⅱ-Ⅳ级aGVHD的发生率可能与CD34细胞计数有关。
