Li Xiang, Chen Pinhong, Liu Guosheng
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Angew Chem Int Ed Engl. 2018 Nov 26;57(48):15871-15876. doi: 10.1002/anie.201810405. Epub 2018 Nov 7.
A palladium-catalyzed intermolecular arylcarbonylation of unactivated alkenes has been developed. Unsymmetrical diaryliodonium salts (DAISs) were used as arylation reagents, the bulky aryl group (Ar ) of which was exclusively incorporated into the arylcarbonylated products, which contained the Ar group and a carboxylic ester group at the α- and β-carbon position, respectively, of the original terminal C-C double bond. The reaction features excellent chemo- and regioselectivity, high functional-group tolerance, and very mild reaction conditions.
已开发出一种钯催化的未活化烯烃分子间芳基羰基化反应。使用不对称二芳基碘鎓盐（DAISs）作为芳基化试剂，其中体积较大的芳基（Ar）专门引入到芳基羰基化产物中，该产物在原始末端碳 - 碳双键的α - 和β - 碳位置分别含有Ar基团和羧酸酯基团。该反应具有出色的化学和区域选择性、高官能团耐受性以及非常温和的反应条件。
