Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, 330045, China.
J Biomed Mater Res A. 2018 Dec;106(12):3034-3041. doi: 10.1002/jbm.a.36493. Epub 2018 Sep 7.
Deposition of amyloid-β (Aβ) aggregates and formation of neurotoxic reactive oxygen species (ROS) are significant pathological signatures of Alzheimer's disease (AD). Resveratrol (Res) is an antioxidant with the potential to treat AD. However, the bioavailability and solubility of Res is very low and it cannot entirely inhibit Cu -induced Aβ42 aggregation at low concentration. Herein, we combine the unique Aβ absorption property of selenium nanoparticles with the natural antioxidant agent Res to form Res@SeNPs. Our in vitro biological evaluation revealed that modification of Res with SeNPs provides a synergistic effect on Cu -induced Aβ42 aggregation, ROS generation and, more importantly, protects PC12 cells from Aβ42-Cu complexes-induced cell death. It is believed that SeNPs can improve the application of Res in AD treatment as Res@SeNPs is more efficient than Res in reducing Aβ42 toxicity in long-term use. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3034-3041, 2018.
淀粉样蛋白-β (Aβ) 聚集体的沉积和神经毒性活性氧 (ROS) 的形成是阿尔茨海默病 (AD) 的重要病理特征。白藜芦醇 (Res) 是一种具有治疗 AD 潜力的抗氧化剂。然而，Res 的生物利用度和溶解度非常低，并且不能在低浓度下完全抑制 Cu 诱导的 Aβ42 聚集。在此，我们将硒纳米粒子的独特 Aβ 吸收特性与天然抗氧化剂 Res 结合起来，形成 Res@SeNPs。我们的体外生物学评估表明，用 SeNPs 修饰 Res 对 Cu 诱导的 Aβ42 聚集、ROS 生成具有协同作用，更重要的是，能保护 PC12 细胞免受 Aβ42-Cu 复合物诱导的细胞死亡。人们相信，由于 Res@SeNPs 在长期使用中比 Res 更能降低 Aβ42 的毒性，因此 SeNPs 可以提高 Res 在 AD 治疗中的应用。© 2018 Wiley Periodicals, Inc. J 生物材料 Res 部分 A:106A:3034-3041,2018.
