Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050095 Bucharest, Romania.
Molecules. 2024 Aug 27;29(17):4056. doi: 10.3390/molecules29174056.
There has been a growing interest recently in exploring the role of the blood-brain barrier (BBB) in the treatment of Alzheimer's disease (AD), a neurodegenerative disorder characterized by cognitive decline and memory loss that affects millions of people worldwide. Research has shown that the BBB plays a crucial role in regulating the entry of therapeutics into the brain. Also, the potential benefits of using antioxidant molecules for drug delivery were highlighted in Alzheimer's treatment to enhance the therapeutic efficacy and reduce oxidative stress in affected patients. Antioxidant-based nanomedicine shows promise for treating AD by effectively crossing the BBB and targeting neuroinflammation, potentially slowing disease progression and improving cognitive function. Therefore, new drug delivery systems are being developed to overcome the BBB and improve the delivery of therapeutics to the brain, ultimately improving treatment outcomes for AD patients. In this context, the present review provides an in-depth analysis of recent advancements in AD treatment strategies, such as silica nanoparticles loaded with curcumin, selenium nanoparticles loaded with resveratrol, and many others, focusing on the critical role of the BBB and the use of antioxidant-based drug delivery systems.
最近，人们对探索血脑屏障（BBB）在治疗阿尔茨海默病（AD）中的作用产生了浓厚的兴趣。AD 是一种神经退行性疾病，其特征是认知能力下降和记忆力丧失，影响着全球数以百万计的人。研究表明，BBB 在调节治疗药物进入大脑方面起着至关重要的作用。此外，在 AD 治疗中使用抗氧化分子进行药物输送的潜在益处也得到了强调，以增强治疗效果并减轻受影响患者的氧化应激。基于抗氧化剂的纳米医学在有效穿过 BBB 并靶向神经炎症方面显示出治疗 AD 的潜力，有可能减缓疾病进展并改善认知功能。因此，正在开发新的药物输送系统以克服 BBB 并提高治疗药物向大脑的输送，从而最终改善 AD 患者的治疗效果。在这种情况下，本综述深入分析了 AD 治疗策略的最新进展，例如负载姜黄素的硅纳米颗粒、负载白藜芦醇的硒纳米颗粒等，重点关注 BBB 的关键作用和基于抗氧化剂的药物输送系统的使用。
