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细胞接触和 TGF-β 信号在激活上皮间质转化（EMT）中的作用。

The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT).

机构信息

a Biomathematics Program , North Carolina State University , Raleigh , NC , USA.

b College of Veterinary Medicine , North Carolina State University , Raleigh , NC , USA.

出版信息

Cell Adh Migr. 2019 Dec;13(1):63-75. doi: 10.1080/19336918.2018.1526597. Epub 2018 Oct 8.

DOI:10.1080/19336918.2018.1526597
PMID:30296203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6527395/
Abstract

The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells. While the SW480 population revealed an intermediate state between the epithelial and mesenchymal states, the MC7 cells exhibited highly adhesive behavior. However, for both cell lines, an exogenous TGF-β signal and a reduction in cellular confluence can push a subgroup of the population towards the mesenchymal phenotype. Together, these results highlight that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.

摘要

上皮间质转化（EMT）是癌细胞通过获得与间充质细胞相关的细胞迁移能力而转移的过程中的一个步骤。这项工作研究了 TGF-β 途径和细胞间接触对结肠（SW480）和乳腺（MCF7）癌细胞 EMT 激活的双重影响。虽然 SW480 群体显示出上皮和间充质状态之间的中间状态，但 MCF7 细胞表现出高度黏附的行为。然而，对于这两种细胞系，外源性 TGF-β 信号和细胞汇合度的降低可以促使一部分群体向间充质表型转化。总之，这些结果表明，尽管 EMT 是由多种信号的协同作用诱导的，但这种激活在不同的细胞类型中有所不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/b20c2564c596/kcam-13-01-1526597-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/33bf7e367466/kcam-13-01-1526597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/61a37853c542/kcam-13-01-1526597-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/25f9ba9a6f20/kcam-13-01-1526597-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/9cd51bcf27ca/kcam-13-01-1526597-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/a0a58ab88ffe/kcam-13-01-1526597-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/b20c2564c596/kcam-13-01-1526597-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/33bf7e367466/kcam-13-01-1526597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/61a37853c542/kcam-13-01-1526597-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/25f9ba9a6f20/kcam-13-01-1526597-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/9cd51bcf27ca/kcam-13-01-1526597-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/a0a58ab88ffe/kcam-13-01-1526597-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c054/6527395/b20c2564c596/kcam-13-01-1526597-g006.jpg

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