Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
Travel Med Infect Dis. 2018 Nov-Dec;26:25-31. doi: 10.1016/j.tmaid.2018.10.003. Epub 2018 Oct 6.
Information on parameters associated with the severity of tick-borne encephalitis (TBE) is limited.
The association between 15 pre-defined parameters and the severity of TBE was evaluated in 717 consecutive adult patients diagnosed in Slovenia 2007-2012.
Multivariable logistic regression showed that patient age (odds ratio, OR 1.26, 95% CI 1.11-1.44; P = 0.001), previous vaccination against TBE (OR 14.23, 95% CI 1.72-117.87; P = 0.014), blood leukocyte count (OR 1.45, 95% CI 1.13-1.85; P = 0.004), and level of specific TBE virus serum IgG antibodies (OR 0.85, 95% CI 0.75-0.96; P = 0.009) were associated with severe acute illness based on the clinical diagnosis. When severity of TBE was based on the severity score and linear regression was used, corresponding association was found for age (estimated coefficient, EC 1.70, 95% CI 1.06-2.33; P<0.001), previous vaccination against TBE (EC 11.16, 95% CI 5.05-17.27; P < 0.001), serum C-reactive protein level (EC 1.20, 95% CI 0.48-1.91; P = 0.001), and level of specific TBE virus serum IgG antibodies (EC -0.74, 95% CI -1.27-0.20; P = 0.007).
Previous vaccination against TBE, low levels of TBE virus serum IgG antibodies, older age, higher blood leukocyte count, and higher serum C-reactive protein levels are associated with more severe TBE.
关于与蜱传脑炎（TBE）严重程度相关的参数信息有限。
在 2007-2012 年于斯洛文尼亚连续诊断的 717 例成年患者中，评估了 15 个预定义参数与 TBE 严重程度之间的关联。
多变量逻辑回归显示，患者年龄（比值比，OR 1.26，95%置信区间 1.11-1.44；P=0.001）、先前接种 TBE 疫苗（OR 14.23，95%置信区间 1.72-117.87；P=0.014）、白细胞计数（OR 1.45，95%置信区间 1.13-1.85；P=0.004）和特定 TBE 病毒血清 IgG 抗体水平（OR 0.85，95%置信区间 0.75-0.96；P=0.009）与根据临床诊断的严重急性疾病相关。当 TBE 的严重程度基于严重程度评分且使用线性回归时，年龄（估计系数，EC 1.70，95%置信区间 1.06-2.33；P<0.001）、先前接种 TBE 疫苗（EC 11.16，95%置信区间 5.05-17.27；P<0.001）、血清 C 反应蛋白水平（EC 1.20，95%置信区间 0.48-1.91；P=0.001）和特定 TBE 病毒血清 IgG 抗体水平（EC-0.74，95%置信区间-1.27-0.20；P=0.007）与更严重的 TBE 相关。
先前接种 TBE 疫苗、TBE 病毒血清 IgG 抗体水平较低、年龄较大、白细胞计数较高和血清 C 反应蛋白水平较高与 TBE 病情更严重相关。
