Adamczuk Justyna, Chlabicz Magdalena, Koda Natalia, Kondrusik Maciej, Zajkowska Joanna, Czupryna Piotr, Moniuszko-Malinowska Anna
Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Students' Scientific Club at the Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Bialystok, Poland.
Pathogens. 2024 Dec 27;14(1):7. doi: 10.3390/pathogens14010007.
Tick-borne encephalitis (TBE) is the most prevalent viral infection of the central nervous system (CNS) in Poland. The disease is characterized by the presence of two stages. The first phase, called the viremic stage, presents with flu-like symptoms, while the second stage of TBE is characterized by damage to the nervous system and may follow a severe and dramatic course. The aim of this paper is to increase the awareness of the potential sequelae after TBE. In this study, we report cases of severe TBE in 36-year-old and 57-year-old female patients. The outcome of TBE varies from patient to patient, but there are some factors that can help to predict the severity of TBE infection. The risk factors presented in these patients were as follows: the monophasic course of TBE, high pleocytosis in cerebrospinal fluid (CSF) and older age. Both of our patients were not vaccinated despite the World Health Organization's (WHO's) recommendations. Both patients had no history of travel outside their region of residence prior to the onset of illness. The few risk factors shown in our patients and the serious sequelae of the disease may indicate the need to test patients for possible gene mutations.
蜱传脑炎（TBE）是波兰最常见的中枢神经系统（CNS）病毒感染。该疾病具有两个阶段。第一阶段称为病毒血症期，表现为流感样症状，而蜱传脑炎的第二阶段以神经系统损伤为特征，可能会经历严重且急剧的病程。本文的目的是提高对蜱传脑炎潜在后遗症的认识。在本研究中，我们报告了一名36岁和一名57岁女性患者的严重蜱传脑炎病例。蜱传脑炎的结果因患者而异，但有一些因素有助于预测蜱传脑炎感染的严重程度。这些患者出现的危险因素如下：蜱传脑炎的单相病程、脑脊液（CSF）中淋巴细胞高度增多以及年龄较大。尽管世界卫生组织（WHO）有建议，但我们的两名患者均未接种疫苗。两名患者在发病前均无居住地区以外的旅行史。我们患者中显示的少数危险因素以及该疾病的严重后遗症可能表明需要对患者进行可能的基因突变检测。
