环氧二十碳三烯酸对肥胖相关胰岛素抵抗中巨噬细胞表型可塑性的免疫代谢调节作用

The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance.

作者信息

Dai Meiyan, Wu Lujin, Tu Ling, Xu Xizhen, Wang Dao Wen

机构信息

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, 430030, China.

Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China.

出版信息

Prostaglandins Other Lipid Mediat. 2018 Nov;139:36-40. doi: 10.1016/j.prostaglandins.2018.10.003. Epub 2018 Oct 5.

DOI:10.1016/j.prostaglandins.2018.10.003

PMID:30296488

Abstract

Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Macrophages display phenotypic plasticity, and polarize under the condition of obesity. Epoxyeicosatrienoic Acids (EETs) are lipid mediators that are involved in the regulation of inflammatory cascades and glucose homeostasis. In this mini-review, we briefly summarize the macrophages recruitment, infiltration and polarization in obese mice, and also discuss the immune-metabolic regulatory role of EETs in this process (See Fig. 1).

摘要

脂肪组织中的巨噬细胞与肥胖诱导的低度炎症相关，这种炎症会导致胰岛素抵抗及相关代谢疾病。巨噬细胞具有表型可塑性，并在肥胖条件下发生极化。环氧二十碳三烯酸（EETs）是参与炎症级联反应和葡萄糖稳态调节的脂质介质。在这篇小型综述中，我们简要总结了肥胖小鼠中巨噬细胞的募集、浸润和极化情况，并讨论了EETs在此过程中的免疫代谢调节作用（见图1）。