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异前列腺素与心血管疾病

Isolevuglandins and cardiovascular disease.

作者信息

Davies Sean S, May-Zhang Linda S

机构信息

Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.

Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.

出版信息

Prostaglandins Other Lipid Mediat. 2018 Nov;139:29-35. doi: 10.1016/j.prostaglandins.2018.10.002. Epub 2018 Oct 5.

DOI:10.1016/j.prostaglandins.2018.10.002
PMID:30296489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6555638/
Abstract

Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.

摘要

异前列烷是由花生四烯酸过氧化形成的4-酮醛。异前列烷能迅速与包括蛋白质赖氨酸残基在内的伯胺发生反应，形成不可逆的共价修饰。本综述重点介绍了异前列烷修饰在疾病过程，尤其是动脉粥样硬化中的潜在作用的证据，以及一些用于评估它们对疾病影响的工具，包括小分子二羰基清除剂。

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Diabetes. 2018 Nov;67(11):2361-2376. doi: 10.2337/db18-0040. Epub 2018 Sep 4.
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Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats.乙酸 2-羟基苯甲胺在小鼠和大鼠中的急性和 28 天重复剂量毒性评价。
Regul Toxicol Pharmacol. 2018 Oct;98:190-198. doi: 10.1016/j.yrtph.2018.07.026. Epub 2018 Jul 31.
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Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function.异莱格素（isolevuglandins），一种高反应性的γ-酮醛，可使高密度脂蛋白的结构和功能受到损伤性改变。
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