异前列腺素与心血管疾病
Isolevuglandins and cardiovascular disease.
作者信息
Davies Sean S, May-Zhang Linda S
机构信息
Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.
Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.
出版信息
Prostaglandins Other Lipid Mediat. 2018 Nov;139:29-35. doi: 10.1016/j.prostaglandins.2018.10.002. Epub 2018 Oct 5.
Abstract
Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.
摘要
异前列烷是由花生四烯酸过氧化形成的4-酮醛。异前列烷能迅速与包括蛋白质赖氨酸残基在内的伯胺发生反应，形成不可逆的共价修饰。本综述重点介绍了异前列烷修饰在疾病过程，尤其是动脉粥样硬化中的潜在作用的证据，以及一些用于评估它们对疾病影响的工具，包括小分子二羰基清除剂。
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本文引用的文献
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Diabetes. 2018 Nov;67(11):2361-2376. doi: 10.2337/db18-0040. Epub 2018 Sep 4.
2
Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats.
Regul Toxicol Pharmacol. 2018 Oct;98:190-198. doi: 10.1016/j.yrtph.2018.07.026. Epub 2018 Jul 31.
3
Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function.
J Biol Chem. 2018 Jun 15;293(24):9176-9187. doi: 10.1074/jbc.RA117.001099. Epub 2018 Apr 30.
4
Reactive Carbonyl Species Scavengers-Novel Therapeutic Approaches for Chronic Diseases.
Curr Pharmacol Rep. 2017 Apr;3(2):51-67. doi: 10.1007/s40495-017-0081-6. Epub 2017 Feb 14.
5
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Sci Rep. 2017 Jun 28;7(1):4350. doi: 10.1038/s41598-017-04100-1.
6
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Free Radic Biol Med. 2017 May;106:62-68. doi: 10.1016/j.freeradbiomed.2017.02.020. Epub 2017 Feb 9.
7
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Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H368-H374. doi: 10.1152/ajpheart.00603.2016. Epub 2016 Dec 16.
8
Accumulation of isolevuglandin-modified protein in normal and fibrotic lung.
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9
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