异前列腺素与心血管疾病
Isolevuglandins and cardiovascular disease.
作者信息
Davies Sean S, May-Zhang Linda S
机构信息
Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.
Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States.
出版信息
Prostaglandins Other Lipid Mediat. 2018 Nov;139:29-35. doi: 10.1016/j.prostaglandins.2018.10.002. Epub 2018 Oct 5.
Abstract
Isolevuglandins are 4-ketoaldehydes formed by peroxidation of arachidonic acid. Isolevuglandins react rapidly with primary amines including the lysyl residues of proteins to form irreversible covalent modifications. This review highlights evidence for the potential role of isolevuglandin modification in the disease processes, especially atherosclerosis, and some of the tools including small molecule dicarbonyl scavengers utilized to assess their contributions to disease.
摘要
异前列烷是由花生四烯酸过氧化形成的4-酮醛。异前列烷能迅速与包括蛋白质赖氨酸残基在内的伯胺发生反应，形成不可逆的共价修饰。本综述重点介绍了异前列烷修饰在疾病过程，尤其是动脉粥样硬化中的潜在作用的证据，以及一些用于评估它们对疾病影响的工具，包括小分子二羰基清除剂。
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