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原α2（V）型胶原蛋白基因在进化上与主要的形成纤维的胶原蛋白相关。

The pro alpha 2(V) collagen gene is evolutionarily related to the major fibrillar-forming collagens.

作者信息

Weil D, Bernard M, Gargano S, Ramirez F

出版信息

Nucleic Acids Res. 1987 Jan 12;15(1):181-98. doi: 10.1093/nar/15.1.181.

DOI:10.1093/nar/15.1.181
PMID:3029669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC340404/
Abstract

A number of overlapping cDNA clones, covering 5.2 kb of sequences which code for the human pro alpha 2(V) collagen chain, have been isolated. Analysis of the structural data have indicated a close evolutionary kinship between the pro alpha 2(V) chain and the major fibrillar collagen types. Isolation and analysis of an 8 kb genomic fragment has further supported this notion by revealing a homologous arrangement of nine triple-helical domain exons. These studies have therefore provided conclusive evidence which categorizes the Type V collagen as a member of the Group 1 molecules, or fibrillar-forming collagens.

摘要

已分离出多个重叠的cDNA克隆，它们覆盖了编码人原α2（V）胶原链的5.2kb序列。对结构数据的分析表明，原α2（V）链与主要的纤维状胶原类型之间存在密切的进化亲缘关系。对一个8kb基因组片段的分离和分析通过揭示九个三螺旋结构域外显子的同源排列进一步支持了这一观点。因此，这些研究提供了确凿的证据，将V型胶原归类为第1组分子或形成纤维的胶原成员。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/340404/95ce5aff2720/nar00245-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/340404/8f0de244b5ef/nar00245-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/340404/95ce5aff2720/nar00245-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/340404/8f0de244b5ef/nar00245-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/340404/95ce5aff2720/nar00245-0198-a.jpg

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本文引用的文献

1
Isolation and characterization of the cyanogen bromide peptides derived from the human alpha 2(V) collagen chain.源自人α2(V)胶原蛋白链的溴化氰肽段的分离与鉴定
Biochemistry. 1981 May 26;20(11):3117-21. doi: 10.1021/bi00514a020.
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Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line.人横纹肌肉瘤细胞系A204合成V型前胶原的过程
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Null alleles of the COL5A1 gene of type V collagen are a cause of the classical forms of Ehlers-Danlos syndrome (types I and II).V型胶原蛋白的COL5A1基因无效等位基因是经典型埃勒斯-当洛综合征（I型和II型）的病因。
Am J Hum Genet. 2000 Jun;66(6):1757-65. doi: 10.1086/302933. Epub 2000 May 4.
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An exon skipping mutation of a type V collagen gene (COL5A1) in Ehlers-Danlos syndrome.埃勒斯-当洛综合征中V型胶原蛋白基因（COL5A1）的外显子跳跃突变。
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Increased expression of basement membrane components in human endothelial cells cultured in high glucose.在高糖培养的人内皮细胞中基底膜成分的表达增加。
J Clin Invest. 1988 Aug;82(2):735-8. doi: 10.1172/JCI113655.
7
Collagen gene expression by cultured human skin fibroblasts. Abundant steady-state levels of type VI procollagen messenger RNAs.培养的人皮肤成纤维细胞的胶原蛋白基因表达。VI型前胶原信使核糖核酸的丰富稳态水平。
J Clin Invest. 1989 Mar;83(3):791-5. doi: 10.1172/JCI113959.
8
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon.人类短链胶原蛋白（XIII型）α1链的基因结构，具有可变剪接转录本且在最后一个外显子的5'端有翻译终止密码子。
Proc Natl Acad Sci U S A. 1988 Oct;85(20):7491-5. doi: 10.1073/pnas.85.20.7491.
9
Characterization of a fibrillar collagen gene in sponges reveals the early evolutionary appearance of two collagen gene families.海绵体中一种纤维状胶原蛋白基因的特征揭示了两个胶原蛋白基因家族的早期进化出现。
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6669-73. doi: 10.1073/pnas.87.17.6669.
10
Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.糖尿病或高糖诱导的纤连蛋白过表达：一种具有记忆性的现象。
Proc Natl Acad Sci U S A. 1990 Jan;87(1):404-8. doi: 10.1073/pnas.87.1.404.
J Cell Biol. 1982 Feb;92(2):343-9. doi: 10.1083/jcb.92.2.343.
4
Sequence determination and analysis of the 3' region of chicken pro-alpha 1(I) and pro-alpha 2(I) collagen messenger ribonucleic acids including the carboxy-terminal propeptide sequences.鸡原α1（I）和原α2（I）型胶原信使核糖核酸3'区域的序列测定与分析，包括羧基末端前肽序列。
Biochemistry. 1981 Feb 17;20(4):996-1006. doi: 10.1021/bi00507a054.
5
A conserved nucleotide sequence, coding for a segment of the C-propeptide, is found at the same location in different collagen genes.在不同的胶原蛋白基因中，编码C-前肽片段的保守核苷酸序列位于相同位置。
Nucleic Acids Res. 1983 May 11;11(9):2733-44. doi: 10.1093/nar/11.9.2733.
6
Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution.人I型前胶原原α1链互补脱氧核糖核酸的核苷酸序列。对进化过程中保守结构的统计学评估。
Biochemistry. 1983 Oct 25;22(22):5213-23. doi: 10.1021/bi00291a023.
7
Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene.人I型前胶原原α2链cDNA的结构。与鸡的原α2（I）链cDNA比较，确定了该蛋白质和基因在结构上保守的特征。
Biochemistry. 1983 Mar 1;22(5):1139-45. doi: 10.1021/bi00274a023.
8
Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide.鸡Ⅱ型原胶原基因的结构与序列。编码羧基末端端肽和前肽区域的特征分析。
J Biol Chem. 1984 Jun 25;259(12):7826-34.
9
Organization of collagen types I and V in the embryonic chicken cornea: monoclonal antibody studies.胚胎鸡角膜中I型和V型胶原蛋白的组织：单克隆抗体研究
Proc Natl Acad Sci U S A. 1984 May;81(9):2791-5. doi: 10.1073/pnas.81.9.2791.
10
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.一种允许在哺乳动物细胞中表达互补DNA插入片段的互补DNA克隆载体。
Mol Cell Biol. 1983 Feb;3(2):280-9. doi: 10.1128/mcb.3.2.280-289.1983.