, San Clemente, California,
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Blood Purif. 2019;47(1-3):62-68. doi: 10.1159/000493178. Epub 2018 Oct 8.
BACKGROUND/AIMS: We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis.
Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely, stdKt/V = N × (URR + UFV/V), where N is the number of treatments per week, URR is urea reduction ratio per treatment, UFV is ultrafiltration volume per treatment, and V is postdialysis urea distribution volume. URR required corrections for postdialysis rebound and intradialytic urea generation. We compared the accuracy of this approach with previous equations for stdKt/V by numerical simulations using a 2-compartment model of urea kinetics for thrice-weekly and more frequent HD prescriptions.
The proposed equation based on urea mass removed predicted values of stdKt/V that are equivalent to those calculated by previous equations for stdKt/V.
This work provides a novel approach for calculating stdKt/V during HD and strengthens the theoretical understanding of stdKt/V.
背景/目的：我们基于尿素质量清除推导了一个新的血液透析（HD）时计算每周尿素标准化 Kt/V（stdKt/V）的方程，与腹膜透析时的方法相当。
对 HD 期间尿素质量平衡的理论考虑导致了以下 stdKt/V 方程，即 stdKt/V = N ×（URR + UFV/V），其中 N 是每周治疗次数，URR 是每次治疗的尿素降低率，UFV 是每次治疗的超滤量，V 是透析后尿素分布量。URR 需要对透析后反弹和透析内尿素生成进行校正。我们通过使用尿素动力学的 2 室模型对每周 3 次和更频繁的 HD 处方进行数值模拟，比较了这种方法与以前的 stdKt/V 方程的准确性。
基于尿素质量清除的建议方程预测的 stdKt/V 值与以前的 stdKt/V 方程计算的值相当。
这项工作为 HD 期间计算 stdKt/V 提供了一种新方法，并加强了对 stdKt/V 的理论理解。
